Results 341 to 350 of about 2,261,376 (387)
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Biochemical Society Transactions, 1988
The concept of the epidermis being a site for the initiation of immune responses has only been developed over the past decade. There is strong evidence that epidermal cells have immune functions. Accordingly the epidermis harbors dendritic cells having antigen presenting capacity and cells belonging to the T-cell family.
T. A. Luger, J. C. Ansel, T. Baba
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The concept of the epidermis being a site for the initiation of immune responses has only been developed over the past decade. There is strong evidence that epidermal cells have immune functions. Accordingly the epidermis harbors dendritic cells having antigen presenting capacity and cells belonging to the T-cell family.
T. A. Luger, J. C. Ansel, T. Baba
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Inhibitory cytokines and cytokine inhibitors
Neurology, 1995Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shedding, by specific inhibitors, and ...
D, Burger, J M, Dayer
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Cytokines and autoantibodies to cytokines
STEM CELLS, 1995Cytokines are essential components of our defense and repair systems but also potentially harmful mediators of infectious and immunoinflammatory reactions. Clinically important cytokines function systemically as pleiotropic hormones with overlapping effects on many cell types. All engage in a complex network of agonists and antagonists.
Bendtzen, Klaus +4 more
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Cytokine-Cytokine Interactions in the Context of Cytokine Networking
American Journal of Respiratory Cell and Molecular Biology, 1992The start of the field of cytokine biology has been variously dated to 1951 with the discovery of nerve growth factor, 1954 with the discovery of interferon, the 1960s with the first description of "lymphokines," and 1966 with the discovery of "migration inhibitory factor" (1).
J A, Elias, R J, Zitnik
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Cytokine, 2006
Genetic variation plays a significant role in the normal functioning of the immune system, and also in the interaction between many common drugs and cellular pathways. With a growing number of cytokine-based therapies now in mainstream clinical use, the prospect of targeting these agents to the individuals likely to benefit from them most is an ...
J R, Maxwell, A G, Wilson
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Genetic variation plays a significant role in the normal functioning of the immune system, and also in the interaction between many common drugs and cellular pathways. With a growing number of cytokine-based therapies now in mainstream clinical use, the prospect of targeting these agents to the individuals likely to benefit from them most is an ...
J R, Maxwell, A G, Wilson
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Current Opinion in Immunology, 1989
Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Is a "Cytokine Storm" Relevant to COVID-19?
JAMA Internal Medicine, 2020In its most severe form, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), leads to a life-threatening pneumonia and acute respiratory distress syndrome (ARDS).
P. Sinha, M. Matthay, C. Calfee
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Inhaled cytokines and cytokine antagonists
Advanced Drug Delivery Reviews, 2006Cytokine and cytokine antagonist have provided novel and effective therapies for many human diseases. A number of approved cytokines including the interferons (alpha, beta and gamma), interleukin-2 (IL-2), granulocyte macrophage colony stimulating factor (GM-CSF) as well as novel cytokine antagonists have been administered by the pulmonary route for ...
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2003
Cytokines are important mediators in inflammation, and play a key role in inflammation induced by Gram-negative bacteria. Cytokines are released into serum during different pathological conditions, such as meningococcal disease, and the cytokine levels in serum seem to correlate with fatal outcome of septic shock (1-3).
N B, Liabakk +4 more
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Cytokines are important mediators in inflammation, and play a key role in inflammation induced by Gram-negative bacteria. Cytokines are released into serum during different pathological conditions, such as meningococcal disease, and the cytokine levels in serum seem to correlate with fatal outcome of septic shock (1-3).
N B, Liabakk +4 more
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Interleukin-6: A Masterplayer in the Cytokine Network
Oncology, 2020Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
P. Uciechowski, W. Dempke
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