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Cytokines in Cytokine Storm Syndrome
2019As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
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Chest, 2000
To review the concept of proinflammatory cytokines.Review of published literature.Academic (university hospital).Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti ...
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To review the concept of proinflammatory cytokines.Review of published literature.Academic (university hospital).Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti ...
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Current Opinion in Immunology, 1991
The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface.
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The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface.
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Veterinary Immunology and Immunopathology, 1994
Cytokines play a central role in modulation of immunological and physiological processes in animals under both homeostatic and abnormal conditions. Currently available information from a variety of species indicates that interleukins, interferons and tumor necrosis factor mobilize immune responses, activate inflammatory reactions and communicate with ...
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Cytokines play a central role in modulation of immunological and physiological processes in animals under both homeostatic and abnormal conditions. Currently available information from a variety of species indicates that interleukins, interferons and tumor necrosis factor mobilize immune responses, activate inflammatory reactions and communicate with ...
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2012
Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins, which exert pleiotropic and redundant effects that promote growth, differentiation and activation of normal cells. Cytokines can have either pro- or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironments. The tumor microenvironment
Masasuke, Ohno +2 more
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Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins, which exert pleiotropic and redundant effects that promote growth, differentiation and activation of normal cells. Cytokines can have either pro- or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironments. The tumor microenvironment
Masasuke, Ohno +2 more
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Science's STKE, 2006
The interplay between the immune system and cancer cells is a complicated one. On the one hand, inflammation associated with tumors is similar to that of protective immune responses and inhibition of responses like turnover of extracellular matrix and angiogenesis, so inhibition of these responses can suppress tumor growth.
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The interplay between the immune system and cancer cells is a complicated one. On the one hand, inflammation associated with tumors is similar to that of protective immune responses and inhibition of responses like turnover of extracellular matrix and angiogenesis, so inhibition of these responses can suppress tumor growth.
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Hematology/Oncology Clinics of North America, 2019
The processes controlled by cytokines may be co-opted by pathologic states, contributing to processes that threaten host well-being. A nuanced understanding of this immense web of chemical communications will allow us to understand the mechanisms and limitations of current therapies and to enhance their therapeutic benefits while minimizing their ...
Ann W, Silk, Kim, Margolin
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The processes controlled by cytokines may be co-opted by pathologic states, contributing to processes that threaten host well-being. A nuanced understanding of this immense web of chemical communications will allow us to understand the mechanisms and limitations of current therapies and to enhance their therapeutic benefits while minimizing their ...
Ann W, Silk, Kim, Margolin
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Cytokine-Cytokine Receptor Structure
Science's STKE, 2005Interleukin-2 (IL-2) is central to the immune response. It forms a complex with three cell surface receptors, IL-2Rα, IL-2Rβ, and IL-2Rγ, to form a complex that signals through activation of downstream tyrosine kinases, JAK3 and STAT. Rickert et al.
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Seminars in Liver Disease, 1999
Cytokines are involved in a number of physiologic and pathophysiologic processes in the liver. These small molecules impact hepatic growth and repair, regulate inflammation, and influence fibrogenesis. Cytokines acting within the liver derive from both resident and recruited cells; the pattern of cytokines produced in a given clinical situation depends
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Cytokines are involved in a number of physiologic and pathophysiologic processes in the liver. These small molecules impact hepatic growth and repair, regulate inflammation, and influence fibrogenesis. Cytokines acting within the liver derive from both resident and recruited cells; the pattern of cytokines produced in a given clinical situation depends
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