Results 21 to 30 of about 166,640 (259)

Molecular and cellular factors determining the functional pleiotropy of cytokines [PDF]

, 2023
Cytokines are soluble factors vital for mammalian physiology. Cytokines elicit highly pleiotropic activities, characterized by their ability to induce a wide spectrum of functional responses in a diverse range of cell subsets, which makes their study ...
Moraga, Ignacio, Elizabeth Pohler, Alison McFarlane, McFarlane, Alison, Ignacio Moraga, Pohler, Elizabeth   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Biologic response of animals to husbandry stress with implications for biomedical models

, 2010
Peer-reviewedThe quality of life of animals is defined by a range of parameters including health, physiology, and behavior. Stress is defined as any damaging strain, force, or agent which stimulates a physiologic defense reaction and is capable under ...
Buckham-Sporer, Kelly, Pang, Wanyong, Gupta, Sandeep, Earley, Bernadette, Ting, Simon   +4 more
core   +1 more source

Between-day reliability of cytokines and adipokines for application in research and practice

, 2022
Purpose: This study assessed the biological reliability of peripheral human cytokines and adipokines, and the influence of participant characteristics on total error.
Schaumberg, Mia A., Flemming, Nicole B., Rose, Grace L, Farley, Morgan J, Flemming, Nicole B, Skinner, Tina L, Schaumberg, Mia A, Skinner, Tina L., Rose, Grace L., Farley, Morgan J., https://orcid.org/   +10 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Correlations between APACHE IIScore and Plasma Levels of Cytokines in Postsurgical Patients [PDF]

, 1996
This study was designed to assess whether plasma cytokines correlated with the clinical status of postsurgical patients. Plasma levels of cytokines in 72 patients admitted to the intensive care unit were measured using an Enzyme Linked Immuno Solubent ...
Haseba, Sumitaka, Niiya, Sadayo, Sumikawa, Koji, Todoroki, Sachiko   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cytokines: Sensors of the nervous system

, 2012
The central nervous system (CNS) and the immune system share multiple chemical messengers ranging from small molecules, such as corticotropin-releasing factor (CRF) to large proteins, such as cytokines and growth factors.
Fafutis-Morris, M., Oscar Kurt Bitzer, Q.   +1 more
core   +1 more source