Results 11 to 20 of about 163,436 (210)

Cytokines in Placental Physiology and Disease [PDF]

Mediators of Inflammation, 2012
The placenta forms connection between growing fetus and uterine wall and is a unique, temporary, highly specialized organ required for the development of the embryo and fetus. In humans, as early as 3-4 days after fertilization trophoblastic cells can be identified on the outer layer of cells within the blastocyst.
Dariusz Szukiewicz, Szukiewicz Dariusz
exaly   +4 more sources

Cytokines and cytokine receptors: physiology and pathological disorders

International Journal of Infectious Diseases, 2003
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Netea, M.G., Meer, J.W.M. van der
openaire   +3 more sources

Roles of Cytokines in Pathological and Physiological Gastroesophageal Reflux Exposure

Journal of Neurogastroenterology and Motility, 2023
Gastroesophageal reflux disease is frequently observed and has no definitive treatment. There are 2 main views on the pathogenesis of gastroesophageal reflux disease. The first is that epithelial damage starts from the mucosa by acidic-peptic damage and the inflammatory response of granulocytes.
Pelin Ergun, Sezgi Kipcak, Nur S Gunel, Serhat Bor, Eser Y Sozmen   +4 more
openaire   +3 more sources

CHARACTERISTICS OF THE CYTOKINE PROFILE IN PHYSIOLOGICAL AND COMPLICATED PREGNANCY [PDF]

IХ Международная научно-практическая конференция, 2021
One of the priority tasks of any state is to protect the health of mothers and children. Despite the great advances in diagnostics and methods for preventing the occurrence of pathologies during pregnancy, the percentage of normal births is decreasing every year.
M.V. Kruglyakova, O.V. Smirnova, N.M. Titova   +2 more
openaire   +1 more source

SAA does not induce cytokine production in physiological conditions [PDF]

Cytokine, 2013
SAA has been shown to have potential proinflammatory properties in inflammatory diseases such as atherosclerosis. These include induction of tumor necrosis factor α, interleukin-6, and monocyte chemoattractant protein 1 in vitro. However, concern has been raised that these effects might be due to use of recombinant SAA with low level of endotoxin ...
Myung-Hee, Kim, Maria C, de Beer, Joanne M, Wroblewski, Nancy R, Webb, Frederick C, de Beer   +4 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source