Results 181 to 190 of about 52,373 (308)

Multiomic Underpinnings of Drug Targets for Intracranial Aneurysm: Evidence From Diversified Mendelian Randomization

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
NT5C2 and PRCP were identified as druggable targets for intracranial aneurysms (IA) with multiomic druggable genome‐wide Mendelian randomization, colocalization analysis, and external validation support. The causal effect of NT5C2 and PRCP on IA was independent of the modifiable IA risk factors, such as high blood pressure, smoking, and insomnia ...
Yu‐Xiang Fan, Di Lu, Cheng‐Bin Yang, Zi‐Hao Song, Yi‐Guang Chen, Yong‐Jie Ma, Jing‐Wei Li, Hong‐Qi Zhang   +7 more
wiley   +1 more source

Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2647-2657, May 2025.
Abstract Objective Roux‐en‐Y gastric bypass (RYGB) surgery has been shown to lead to favourable health outcomes in obese patients. However, the molecular changes that occur and how they relate to clinical measures are poorly understood. Here, we characterise the proteomic alterations that occur in plasma of RYGB patients before and 9 months after ...
Hasnain Ahmed, Marco F. Fernandes, Kazim Abbas, Silvia A. Synowsky, Sally L. Shirran, Ramzi A. Ajjan, Alan J. Stewart   +6 more
wiley   +1 more source

The role of indole‐3‐acetic acid and characterization of PIN transporters in complex streptophyte alga Chara braunii

New Phytologist, Volume 246, Issue 3, Page 1066-1083, May 2025.
Summary Auxin, indole‐3‐acetic acid (IAA), is a key phytohormone with diverse morphogenic roles in land plants, but its function and transport mechanisms in algae remain poorly understood. We therefore aimed to explore the role of IAA in a complex, streptophyte algae Chara braunii. Here, we described novel responses of C.
Katarina Kurtović, Stanislav Vosolsobě, Daniel Nedvěd, Karel Müller, Petre Ivanov Dobrev, Vojtěch Schmidt, Piotr Piszczek, Andre Kuhn, Adrijana Smoljan, Tom J. Fisher, Dolf Weijers, Jiří Friml, John L. Bowman, Jan Petrášek   +13 more
wiley   +1 more source

Enhancing sweet potato production: a comprehensive analysis of the role of auxins and cytokinins in micropropagation. [PDF]

Planta
Adu Donyina G, Szarvas A, Opoku VA, Miko E, Tar M, Czóbel S, Monostori T.   +6 more
europepmc   +1 more source

Structure‐guided insights into the biology of fungal effectors

New Phytologist, Volume 246, Issue 4, Page 1460-1477, May 2025.
Summary Phytopathogenic fungi cause enormous yield losses in many crops, threatening both agricultural production and global food security. To infect plants, they secrete effectors targeting various cellular processes in the host. Putative effector genes are numerous in fungal genomes, and they generally encode proteins with no sequence homology to ...
Marie Le Naour‐‐Vernet, Mounia Lahfa, Josephine H. R. Maidment, André Padilla, Christian Roumestand, Karine de Guillen, Thomas Kroj, Stella Césari   +7 more
wiley   +1 more source

Induction of microspore embryogenesis in bread wheat by mannitol pre-treatment is associated with the disruption of endogenous hormone balance and substantial accumulation of auxins. [PDF]

BMC Plant Biol
Springer A, Krzewska M, Dubas E, Kopeć P, Plačková L, Doležal K, Weigt D, Żur I.   +7 more
europepmc   +1 more source

A system genetics analysis uncovers the regulatory variants controlling drought response in wheat

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1565-1584, May 2025.
Summary Plants activate a variable response to drought stress by modulating transcription of key genes. However, our knowledge of genetic variations governing gene expression in response to drought stress remains limited in natural germplasm. Here, we performed a comprehensive analysis of the transcriptional variability of 200 wheat accessions in ...
Bin Chen, Yuling Liu, Yanyan Yang, Qiannan Wang, Shumin Li, Fangfang Li, Linying Du, Peiyin Zhang, Xuemin Wang, Shuangxing Zhang, Xiaoke Zhang, Zhensheng Kang, Xiaojie Wang, Hude Mao   +13 more
wiley   +1 more source

Characterization of a cytokinin-binding protein locus in <i>Mycobacterium tuberculosis</i>. [PDF]

J Bacteriol
Yoo JH, Santarossa C, Thomas A, Ekiert D, Darwin KH.   +4 more
europepmc   +1 more source

LsBLH2–LsOFP6–LsKANT3 module regulates bolting by orchestrating the gibberellin biosynthesis and metabolism in lettuce

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1668-1682, May 2025.
Summary Lettuce is one of the most important vegetables worldwide. Bolting time is an important agronomic trait in lettuce production. Premature bolting reduces crop quality and marketability. Here, we genetically clone the LsBLH2 gene controlling bolting time in lettuce. LsBLH2 encodes a BEL1‐like homeodomain protein.
Haoyu Chen, Yetong Qi, Yong Wang, Jie Liu, Ruirui Lu, Xinhui Zhao, Ruiyu Chen, Yueji Wang, Lei Zhu, Shouru Sun, Jianbin Hu, Luming Yang, Guanghui An   +12 more
wiley   +1 more source

Extracellular ATP: an emerging multifaceted regulator of plant fitness

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1771-1782, May 2025.
Summary Adenosine 5′‐triphosphate (ATP) is the energy currency of living organisms and the primary form of organic phosphate (Po) involved in cellular metabolism. In plants, some ATP is released into the extracellular matrix (ECM) in response to various stimuli, where it functions as extracellular ATP (eATP), a key signalling molecule.
De Peng Yuan, Daewon Kim, Yuan Hu Xuan
wiley   +1 more source