Results 141 to 150 of about 194,896 (265)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Koilocytosis in LSIL Cytology Has Limited Predictive Value for CIN2+ in HPV-Positive Women: Implications for Risk-Based Cytology Triage. [PDF]

Pathogens
Misawa Y, Mizuno S, Honda S, Shinohara R, Kikuchi K, Settsu R, Okayama K, Fujii M, Oda M, Okodo M.   +9 more
europepmc   +1 more source

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

Successful simplified genomic profiling of cytology specimens using Aspyre Clinical Test for Lung (Tissue). [PDF]

Cancer Cytopathol
Gentile C, Herlihy SE, Shapiro E, Evans RT, Green AS, King C, Rossi MB, Gillon-Zhang E, Schaffernoth J, Knudsen KE, Kiser C, Yuen T, Silva AL, Gray ER, Balmforth BW, Levin WJ, Gregg J, Van Deerlin V.   +17 more
europepmc   +1 more source

Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Graphical summary of the study design, intervention, and outcomes. ABSTRACT Background Patients with biliary tract cancer (BTC) often have actionable mutations, and comprehensive genomic profiling (CGP) plays an important role. However, the feasibility of CGP using transpapillary biopsy (TPB) samples remains unclear.
Kazuya Miyamoto, Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Hirohumi Inoue, Ryosuke Sato, Akihiro Matsumi, Yuki Fujii, Daisuke Uchida, Motoyuki Otsuka   +9 more
wiley   +1 more source

Implications of the ElaTION trial for ultrasound based management of thyroid nodules. [PDF]

Gland Surg
Fernández Velasco P, Díaz Soto G.
europepmc   +1 more source

Sonographic localisation of lymph nodes suspicious of metastatic breast cancer to surgical axillary levels

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 119-138, March 2025.
Sonographic imaging is used to identify the presence, number and location of malignant lymph nodes. Axillary lymph nodes suspicious of harbouring breast cancer metastasis can be localised to three surgical axillary levels. This paper will unpack the axillary anatomy, muscular sonographic landmarks, surgical axillary lymph node levels and the ...
Michelle Fenech, Tracey Burke, Grace Arnett, Alisha Tanner, Natasha Werder   +4 more
wiley   +1 more source

Twelve-year trends in cervical cytology screening: a retrospective analysis of 83,148 smears from a Turkish tertiary care center. [PDF]

Front Public Health
Guzelbag B, Uzuner EG, Selcuk M, Ermin S, Ozgun Selcuk CG, Cim N.   +5 more
europepmc   +1 more source

The Role of Routine Staging Laparoscopy for Pancreatic Adenocarcinoma in Underserved Populations: A 14‐Year Experience at a Safety‐Net Hospital

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background There are no consensus guidelines for staging laparoscopy (SL) in pancreatic ductal adenocarcinoma (PDAC) and existing data largely reflect insured referral populations. Routine SL has not been studied in underserved patient populations who face disparities in cancer diagnosis and treatment.
David M. Holmes, Jose Euberto Mendez Reyes, Cary Hsu, Eric J. Silberfein   +3 more
wiley   +1 more source

Artificial intelligence-assisted rapid on-site evaluation in liver biopsy: a diagnostic accuracy study. [PDF]

Front Oncol
Du CC, Chen YX, Li CH, Meng H, Kong FL.
europepmc   +1 more source