Results 81 to 90 of about 4,161 (148)

Fetal cerebral ventriculomegaly: What do we tell the prospective parents?

Prenatal Diagnosis, Volume 42, Issue 13, Page 1674-1681, December 2022., 2022
Abstract Fetal cerebral ventriculomegaly is a relatively common finding, observed during approximately 1% of obstetric ultrasounds. In the second and third trimester, mild (≥10 mm) and severe ventriculomegaly (≥15 mm) are defined according to the measurement of distal lateral ventricles that is included in the routine sonographic examination of central
Veronica Giorgione, Karina Krajden Haratz, Shlomi Constantini, Roee Birnbaum, Gustavo Malinger   +4 more
wiley   +1 more source

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency

British Journal of Clinical Pharmacology, EarlyView.
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky   +3 more
wiley   +1 more source

Congenital cytomegalovirus infection: new answers to old problems

Детские инфекции (Москва)
Congenital cytomegalovirus infection is one of the most common TORCH infections, characterized by a wide range of clinical manifestations, predominantly with multiple organ lesions and often a disabling course.
Ya. R. Khizhak, H. A. Sarkisyan, A. A. Komarova, V. A. Mironova, I. V. Zhuravleva, M. A. Sarkisyan, P. V. Shumilov   +6 more
doaj   +1 more source

Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Increasing demand for recombinant adeno‐associated virus (rAAV)‐based gene therapies necessitates increased manufacturing production. Transient transfection of mammalian cells remains the most commonly used method to produce clinical‐grade rAAVs due to its ease of implementation.
Tam N. T. Nguyen, Damdae Park, Christopher T. Canova, Jose Sangerman, Prasanna Srinivasan, Rui Wen Ou, Paul W. Barone, Caleb Neufeld, Jacqueline M. Wolfrum, Stacy L. Springs, Anthony J. Sinskey, Richard D. Braatz   +11 more
wiley   +1 more source

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green, Qiang Fu, Nelson Ndhairo, Thomas M. Leibiger, Yongdan Wang, Yongsuk Lee, Kelvin H. Lee, Michael Betenbaugh, Seongkyu Yoon, David J. McNally   +9 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Cytomegalovirus Active Infection in Persons Infected with Human Immunodeficiency Virus

Medical Laboratory Journal, 2014
Background and Objective: Cytomegalovirus (CMV), one of the most common opportunistic pathogens in patients infected with human immunodeficiency virus (HIV), can cause the diseases such as encephalitis, pneumonia, and chorioretinitis. This study aimed at
H Ghaffari, A Moradi, A Ghaemi, N Javid, M Talkhabifard, H Naziri, A Tabaraei   +6 more
doaj  

HUMAN CYTOMEGALOVIRUS INFECTION AND SUB-OCCLUSIVE INTESTINAL SYNDROME IN AN INFANT

Romanian Journal of Oral Rehabilitation, 2017
Human Cytomegalovirus is known to be the most common cause of congenital and perinatal infection in developed countries. The gastrointestinal involvement is not usually found among its’ most frequent clinical presentations.
Gabriela Paduraru, Marin Burlea, Anca Adam, Vasile Valeriu Lupu, Ancuta Ignat   +4 more
doaj  

Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well‐designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross‐institutional and international research, especially ...
Jingshuang Yan, Rongrong Ren, Ruqi Chang, Wanyue Dan, Xiaohan Zhang, Fei Pan, Bin Yan, Hongzhe Lee, Ni Josie, Gang Sun, Lihua Peng, Gary D. Wu, Yunsheng Yang   +12 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source