Results 71 to 80 of about 14,151 (225)

Cytomegalovirus Retinitis: Decreased Risk of Bilaterality with Increased Use of Systemic Treatment [PDF]

, 2017
Cytomegalovirus (CMV) retinitis may be treated systemically or intravitreally. We reviewed retrospectively patients with CMV retinitis, in order to determine whether systemic treatment was associated with less spread of CMV retinitis from one eye to the ...
Gabriel, Victor, Herbort, Carl P., Hirschel, Bernard, Olmari, Maya, Opravil, Milos, Overbeck, Jan von, Sansonetti, Alessandra, Stalder, Nicole, Sudre, Philippe   +8 more
core  

Characterisation of Antisense Oligonucleotides by Ion‐Pair Reversed‐Phase UHPLC‐HRMS: Method development using Design of Experiments

Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.
ABSTRACT The quality control of therapeutic antisense oligonucleotides (ASOs) poses significant analytical challenges due to the complexity of their synthesis and degradation processes and the need to ensure the safety and efficacy of active pharmaceutical ingredients (APIs).
Antonio Triolo, Fabiana Tavani, Prisca Barnini, Sandra Furlanetto, Serena Orlandini   +4 more
wiley   +1 more source

Cytomegalovirus Reactivation During Therapy for Pediatric Acute Lymphoblastic Leukemia

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Cytomegalovirus (CMV) reactivation is a recognized complication after hematopoietic stem cell transplantation, but its relevance during conventional chemotherapy for pediatric acute lymphoblastic leukemia (ALL) is poorly defined, especially in CMV‐prevalent regions. This retrospective cross‐sectional study was conducted at a tertiary pediatric
Archana Melavarige Venkatagiri, Neha Reddy, Rhea Chandwani, Nishanth Shekar, Swathi Perampalli Manjunath, Emine Abdu Rahiman, Chiranjay Mukhopadhyay, Vasudeva Bhat Kalya   +7 more
wiley   +1 more source

Evaluating quality of patient‐reported outcome measures in keratitis: A systematic review

Optometry and Vision Science, Volume 103, Issue 4, April 2026.
ABSTRACT Purpose To evaluate the quality of existing patient‐reported outcome measures (PROMs) used to assess the impact of keratitis on the quality of life (QoL). Methods A literature search was conducted using Embase, PubMed, Scopus, Web of Science, CINAHL, and PsycINFO. The review included PROMs used to assess the impact of keratitis on QoL. Data on
Haile W. Alemu, Sheela E. Kumaran, Nicole Carnt, Aragaw K. Assaye, Pawan Baral, Konrad Pesudovs   +5 more
wiley   +1 more source

Absence of intraocular infections after hematopoietic stem cell transplantation at a single center: The experience with current preventive regimens [PDF]

, 2014
Purpose: To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT). Methods: The study design was a single institutional retrospective noncomparative cohort of 135 consecutive patients in 2006 and 2007 ...
Boome, L.C.J. (Liane ) te, Lokhorst, H.M. (Henk), Riemens, A. (Anjo), Rothová, A. (Aniki), Stoyanova, V. (Violeta)   +4 more
core   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, Volume 13, Issue 17, 23 March 2026.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Valacyclovir in the treatment of acute retinal necrosis [PDF]

, 2012
Background: To report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN). Methods: This study reports a retrospective, interventional case series of nine consecutive patients with ten eyes ...
A Aizman, A Urayama, B Meghpara, CH Lau, Claire Y Hooper, CM Perry, DA Palay, DY Chong, E Ezra, GG Emerson, GN Holland, GN Holland, IM Aslanides, J Hillenkamp, J Lycke, J Soul-Lawton, JA Crapotta, Jiten Morarji, JJ O’Brien, JL Sims, KJ Vigil, KR Beutner, Lavnish Joshi, M Hoglund, MD Carney, MD de Smet, MD Tibbetts, MS Blumenkranz, MS Figueroa, Nitin Gupta, PM Falcone, R Nussenblatt, R Wong, Robin Hamilton, S Weller, Simon RJ Taylor, Sue L Lightman, T Kawaguchi, V Savant, WR Bell, WW Culbertson, Y Guex-Crosier   +41 more
core   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

A Young Immunocompetent Cytomegalovirus Retinitis Patient

Novelty in Biomedicine, 2019
Background: Rare cases if CMV retinitis were presented in immunocompetent patients (Nine cases) Cases Report: A 23 years old man with chief complain of sudden decrease of visual acuity and floater in left eye was under investigation.
Rahim Naseri, Shahnaz Sali, Anita Yazdani, Salime Peyghan   +3 more
doaj   +1 more source

Cytomegalieviruserkrankungen bei HIV-Infektion - Auftreten und Prognose im Zeitalter der antiretroviralen Kombinationstherapie [PDF]

, 2010
Mit der vorliegenden Arbeit soll untersucht werden, in welchen klinischen Situationen heutzutage eine CMV-Erkrankung bei HIV-infizierten Patienten in Deutschland auftritt, wie die Langzeitprognose dieser Patienten ist und welche prognostische Bedeutung ...
Pöppl, Stephan
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