Results 221 to 230 of about 615,339 (319)

Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway. [PDF]

Front Immunol
Li X, Meng W, Wang X, Huang S, Wang J, Liang H, Si D.   +6 more
europepmc   +1 more source

Binding of histamine and histamine analogs to lymphocyte subsets analyzed by flow cytometry. [PDF]

, 1985
Katherine Muirhead, Paul E. Bender, Nabil Hanna, George Poste   +3 more
openalex   +1 more source

High‐Yield Bioproduction of Extracellular Vesicles from Stem Cell Spheroids via Millifluidic Vortex Transport

Advanced Materials, EarlyView.
Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot, Laura Charnay, Noa Burshtein, Jean‐Michel Guigner, Léonie Dec, Damarys Loew, Amanda K.A. Silva, Anke Lindner, Claire Wilhelm   +8 more
wiley   +1 more source

Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production. [PDF]

PLoS Pathog
Xu Q, Liu X, Heng H, Wang H, Chen K, Chan EW, Yang G, Chen S.   +7 more
europepmc   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Therapeutic potential of isochlorogenic acid A from <i>Taraxacum officinale</i> in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer. [PDF]

Front Immunol
Wang T, Sun J, Wang L, Lin Y, Wu Z, Jia Q, Zhang S, An J, Ma X, Wu Q, Su Z, Wang H.   +11 more
europepmc   +1 more source

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

Advanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa, Marija Dimitrievska, Cong Wang, Chenlei Gu, Ningjia Sun, Katarzyna Romańczuk, Pawel Karpinski, Łukasz Łaczmański, John A. McGrath, Joanna Jacków‐Malinowska, Ciro Chiappini   +10 more
wiley   +1 more source

Automated cytometric gating with human-level performance using bivariate segmentation. [PDF]

Nat Commun
Chen J, Ionita M, Feng Y, Lu Y, Orzechowski P, Garai S, Hassinger K, Bao J, Wen J, Duong-Tran D, Wagenaar J, McKeague ML, Painter MM, Mathew D, Pattekar A, Meyer NJ, Wherry EJ, Greenplate AR, Shen L.   +18 more
europepmc   +1 more source

SPURIOUS LYMPHOCYTE PHENOTYPES BY FLOW CYTOMETRY FROM MONONUCLEAR CELLS PREPARED BY FICOLL-HYPAQUE [PDF]

, 1987
Herbert B. Slade, Jay H. Greenwood, Jerry L. Hudson, Robert H. Beekman, J. Philip McCoy, Standley A Schwartz   +5 more
openalex   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source