Results 251 to 260 of about 615,339 (319)

Synthesis of Rhodamine TEMPO Conjugates via Isonitrile‐Based Multicomponent‐Reactions for Mitochondria‐Targeted ROS‐Detection in Cancer Cells

open access: yesAdvanced Sensor Research, EarlyView.
This article explores the development of rhodamine TEMPO conjugates via the Ugi‐multicomponent reaction to detect reactive oxygen species (ROS) in living cells. The sensors are highly selective for mitochondria in both cancer and normal cell lines, with fluorescence quenching and EPR spectroscopy offering precise ROS detection.
Haider N. Sultani   +6 more
wiley   +1 more source

Tubeimoside I induces mitophagy by activating the PINK1/Parkin/Mfn2 signaling pathway in acute myeloid leukemia cells. [PDF]

open access: yesTransl Oncol
Xu J   +10 more
europepmc   +1 more source

Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

open access: yesAdvanced Therapeutics, EarlyView.
Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang   +7 more
wiley   +1 more source

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

open access: yesAdvanced Science, EarlyView.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu   +21 more
wiley   +1 more source

FLOW CYTOMETRY IN URINARY TRACT MALIGNANCIES

open access: bronze, 1982
Takeshi Matsuura   +2 more
openalex   +2 more sources

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

open access: yesAdvanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi   +18 more
wiley   +1 more source

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