Results 251 to 260 of about 1,044,820 (327)

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

Programmed cell death regulates hematopoietic cell homeostasis under radiation conditions. [PDF]

Stem Cell Res Ther
Shu M, Zhang J, Peng Y, Li Z, Shu X, Wang J, Zeng H, Shao L.   +7 more
europepmc   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

A high-accuracy, low-cost blood test for Alzheimer's disease: validating P-tau181/Aβ42 in real-world cohorts. [PDF]

Front Aging Neurosci
Liu D, Li H, Liu Q, Li H, Tang Y, Cheng K, Li T, Chu Y, Jia X, Yu W, Zhou H, Yan K.   +11 more
europepmc   +1 more source

Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Semiconducting polymer nanoparticles (SPNs) exhibit many advantageous optical and biological properties. Multimodal SPN‐based contrast agents that integrate several imaging modalities yield a wealth of information through the use of different imaging mechanisms.
Faysal A. Farah, Yu Qin, Mark A. Green, James D. E. T. Wilton‐Ely   +3 more
wiley   +1 more source

Development of a specific anti-human EphA3 monoclonal antibody, Ea₃Mab-20, for flow cytometry. [PDF]

Biochem Biophys Rep
Satofuka H, Suzuki H, Hirose M, Shinoda K, Nakamura T, Tanaka T, Kaneko MK, Kato Y.   +7 more
europepmc   +1 more source

Mononuclear cells in the extraembryonic and intraembryonic coelom of the mouse embryo: A semithin light microscopic cytometry.

, 1989
Kazunobu Sasaki, George Matsumura
openalex   +2 more sources

RBC Membrane‐Camouflaged Nanosystem‐Mediated Synergistic Drug Combination for Enhanced Anti‐Tumor Therapy

Advanced Healthcare Materials, EarlyView.
An RBC membrane camouflaged, cell‐penetrating peptides R8‐based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), inducing tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer.
Qian Cheng, Xuemei Zhong, Lu Deng, Xinling He, Miaoxizi Luo, Ruibing Wang, Jinming Zhang   +6 more
wiley   +1 more source

Functionalization of rare-earth nanoparticles with hybrid silica-lipid shells for T-cell labeling.

Biomater Sci
Kataria S, Belcher AM.
europepmc   +1 more source

Integrating taxonomic and phenotypic information through FISH-enhanced flow cytometry for microbial community dynamics analysis. [PDF]

Microbiol Spectr
Mattelin V, Van Landuyt J, Kerkhof F-M, Minnebo Y, Boon N.   +4 more
europepmc   +1 more source