Results 291 to 300 of about 937,182 (344)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Evaluating cell viability assessment techniques: a comparative study of flow cytometry and fluorescence microscopy in response to bioactive glass exposure. [PDF]

Biomed Eng Online
Samuel BJ, Jin Z, Brauer DS, Matziolis G, Horbert V.   +4 more
europepmc   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Progenitor exhausted PD-1⁺ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis. [PDF]

Nat Cardiovasc Res
Mulholland M, Chalou A, Andersson SHA, Depuydt MAC, Yu Y, Lin S, Tallbäck K, Ericsson A, Jakobsson G, de Mol J, Kryvokhyzha D, Lichtman AH, Foks AC, Schiopu A, Björkbacka H, Slütter B, Gisterå A, Engelbertsen D.   +17 more
europepmc   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

Establishing disease-specific thresholds for automated hematopoietic progenitor cell counting in hematological malignancies. [PDF]

PLoS One
Taka O, Thedsawad A, Owattanapanich W.
europepmc   +1 more source

Enhancing diagnostic precision: a multicentric study of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in lymphoproliferative disorders. [PDF]

ERJ Open Res
Ariza-Prota M, Pérez-Pallarés J, Barisione E, Cruz-Rueda JJ, Onyancha S, Usturoi D, De Santis M, Salcedo-Lobera E, Ferrer-Pargada D, Corcione N, Caballero-Vázquez A, Rodríguez-Blanco I, Torres-Rivas H, Fernández-Fernández L, Velasco-Albendea FJ, García-Clemente M, López-González F.   +16 more
europepmc   +1 more source

Comparative analysis of RT-qPCR, flow cytometry, and Di-4-ANEPPDHQ fluorescence for distinguishing macrophages phenotypes. [PDF]

Biochem Biophys Rep
Siniyeh AA, Alshaer W, Elzogheir N, Al-Holi M, Alqudah DA, Abuarqoub D, Kwiatek JM.   +6 more
europepmc   +1 more source

Envirotune-CAR-T: a hypoxia-responsive and glutamine-enhanced CAR-T cell therapy for overcoming tumor microenvironment-mediated suppression. [PDF]

J Immunother Cancer
Li W, Chen J, Li J, Wang S, Chen Z, Zhao L, Zhao Y, Gu L, Liu J, Zhang Y, Yang X, Chen T, Guo Z.   +12 more
europepmc   +1 more source

Correction: LncRNA NUTM2A-AS1 silencing inhibits glioma via miR-376a-3p/YAP1 axis. [PDF]

Cell Div
Zeng Y, Yang Z, Yang Y, Wang P.
europepmc   +1 more source