Results 311 to 320 of about 1,316,167 (378)

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy. [PDF]

Sci Rep
Nitta K, Shigeyasu K, Kondo Y, Umeda H, Takahashi T, Moriwake K, Yoshida K, Takeda S, Matsumi Y, Kishimoto H, Fuji T, Yasui K, Takagi K, Kayano M, Nakamura S, Michiue H, Yamamoto H, Kanaya N, Kondo Y, Miyake E, Yoshida Y, Shoji R, Kakiuchi Y, Tazawa H, Kagawa S, Fujiwara T.   +25 more
europepmc   +1 more source

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus. [PDF]

Sci Adv
Zhang H, Wang H, Li Y, Fan Y, Zhang Z, Chen H, Song K, Huang L, Zhu P.   +8 more
europepmc   +1 more source

Host Ferritin Translocates into the Chlamydial Inclusion: A Clear Alteration in its Subcellular Distribution as a Result of Infection [PDF]

, 2011
Al-Younes, H., Meyer, T.
core   +1 more source

Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti‐Inflammatory Treatment Efficacy in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
Triblock copolymer‐reinforced liposomal mimics of extracellular vesicles are engineered with tunable membrane elasticity. A semi‐elastic formulation (Tri‐ARTEX8:2) co‐encapsulating stem cell cytosolic extract and AntagomiR155 targets inflamed joints via the ELVIS effect, reprograms macrophages from M1 to M2, and markedly alleviates collagen‐induced ...
Dahwun Kim, Hwira Baek, Su Yeon Lim, Min Sang Lee, Siyan Lyu, Jihyun Lee, Tun Naw Sut, Marta Gonçalves, Jeong Yi Kang, Joshua A. Jackman, Jin Woong Kim, Ji Hoon Jeong   +11 more
wiley   +1 more source

Revisiting the early event of African swine fever virus DNA replication. [PDF]

J Virol
Weng W, Wang H, Ye M, Hu D, Wu J, Qu Y, Gao P, Zhang Y, Zhou L, Ge X, Guo X, Han J, Yang H.   +12 more
europepmc   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress

Alonso Baez L, Bjørkøy A, Saffioti F, Morghen S, Amanda D, Tichá M, Besten M, Ivanova A, Sprakel J, Stokke BT, Hamann T.   +10 more
europepmc   +1 more source

An Insight into Cancer Cells and Disease Progression Through the Lens of Mathematical Modeling. [PDF]

Curr Issues Mol Biol
Michalakis P, Vasilaki D, Abdallah AJ, Asikis C, Niakou A, Stratos A, Tsouknidas A, Johnstone E, Michalakis K.   +8 more
europepmc   +1 more source