Results 151 to 160 of about 420,555 (284)

The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode [PDF]

open access: yes, 2005
Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even
  +204 more
core   +3 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

Detection and Phylogenetic Affiliation of Wolbachia Endosymbiont from Drosophila Melanogaster (India) [PDF]

open access: yes, 2015
The cellular endosymbiont Wolbachia causes reproductive alterations in arthropod and nematode species. The presence of Wolbachia in natural populations of arthropods is made possible by their ability to manipulate the physiology of their host. This study
Puttaraju, H.P.   +2 more
core   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

open access: yesAdvanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong   +13 more
wiley   +1 more source

Amyloid prions in fungi [PDF]

open access: yes, 2016
Prions are infectious protein polymers that have been found to cause fatal diseases in mammals. Prions have also been identified in fungi (yeast and filamentous fungi), where they behave as cytoplasmic non-Mendelian genetic elements.
Aguzzi   +122 more
core   +2 more sources

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo   +5 more
wiley   +1 more source

Genetic Diversity and Wolbachia Infection Patterns in a Globally Distributed Invasive Ant. [PDF]

open access: yes, 2019
Understanding the phylogeographic history of an invasive species may facilitate reconstructing the history and routes of its invasion. The longhorn crazy ant, Paratrechina longicornis, is a ubiquitous agricultural and household pest throughout much of ...
Lee, Chow-Yang   +6 more
core   +2 more sources

Evolutionary Genetics of Cytoplasmic Incompatibility Genes cifA and cifB in Prophage WO of Wolbachia

open access: yesbioRxiv, 2017
The bacterial endosymbiont Wolbachia manipulates arthropod reproduction to facilitate its maternal spread through populations. The most common manipulation is cytoplasmic incompatibility (CI): Wolbachia-infected males produce modified sperm that cause ...
Amelia R. I. Lindsey   +5 more
semanticscholar   +1 more source

Wolbachiasuperinfections and the expression of cytoplasmic incompatibility

open access: yesProceedings of the Royal Society of London. Series B: Biological Sciences, 1995
Strains of Drosophila simulans from Riverside, California (DSR) and Hawaii (DSH) harbour distinct strains of the cytoplasmic incompatibility microorganism Wolbachia, resulting in the expression of bidirectional incompatibility when crossed. D. simulans lines carrying both of these (superinfected) Wolbachia strains were generated by the transfer of ...
Sinkins, S. P.   +2 more
openaire   +3 more sources

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

open access: yesAdvanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova   +8 more
wiley   +1 more source

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