Results 191 to 200 of about 2,354,542 (267)

Morinda Officinalis Oligosaccharides Alleviate Post‐Stroke Depression‐Like Behaviors Alongside Increased Gut Microbial Diversity and Butyrate Levels and Reduced Hippocampal Pla2g4a Expression

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
The mechanism by which MOO alleviates PSD in mice involves remodeling the gut microbiota to increase butyrate, thereby repairing the intestinal barrier and the blood–brain barrier. MOO and butyrate downregulate the hippocampal neuroinflammatory target Pla2g4a, while hippocampal overexpression of Pla2g4a counteracts the antidepressant effects of ...
Hui Ma, Yue Chen, Xinzhou Deng, Xuan Fang, Wenhui Xiao, Qian Long, Lu Du, Fuze Du, Haonan Chen, Yan Wang, Bo Gao, Xin Qiao   +11 more
wiley   +1 more source

Piezo1‐mediated unfolded protein response in goblet cells regulates intestinal mucus barrier homeostasis through the Ca2+–IRE1α–XBP1 pathway

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This study demonstrates that activation of Piezo1 channels in goblet cells by intestinal mechanical stimulation modulates ER calcium homeostasis via calcium ion (Ca2+) flux, which in turn regulates Mucin2 production and synthesis through the IRE1α‐XBP1. Intraperitoneal administration of Yoda1 alleviates mucus barrier impairment in DSS/WAS‐treated mice.
Jiandi Wu, Shaotong Wang, Zhe Wang, Jianhua Fang, Xueyan Li, Qingqing Zhang, Yan Dai, Wenjing Tian, Yize Ma, Gangping Li, Lei Zhang, Yudong Jiang, Xiaohua Hou, Jun Song   +13 more
wiley   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Harnessing mitochondrial genome editing for crop improvement: principles and applications. [PDF]

aBIOTECH
Xu F, Fan F, Cui J, Bai Q, He D, Hu Z, Zhang M, Yang J.   +7 more
europepmc   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

Non-functional allele of <i>RESTORER OF FERTILITY 4</i> is functional for the reduction of <i>orf288</i> RNA in <i>japonica</i> rice. [PDF]

Plant Biotechnol (Tokyo)
Toriyama K, Iwai Y, Takeda S, Takatsuka A, Igarashi K, Kazama T.   +5 more
europepmc   +1 more source

Ursodeoxycholic Acid Confers Neuroprotection in Rats With Acute Cervical SCI and Attenuates NLRP3/Caspase‐1/GSDMD Pyroptotic Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Ursodeoxycholic Acid could inhibit activation of the NLRP3/Caspase‐1/GSDMD pyroptosis pathway and reduce the release of downstream inflammatory cytokines IL‐18 and IL‐1β in rats with acute C5 cervical SCI. This modulation is associated with attenuated secondary injury and improved functional outcomes.
Honghu Song, Xiaomin Hu, Dan Liu, Linjie Wang, Li Zhu, Wenchun Wang, Rongnan Hu, Jiayan Zhong, Jiancheng Liu, Rizhao Pang, Anren Zhang   +10 more
wiley   +1 more source

Rare Feline Gingival Extramedullary Plasmacytoma: Clinical Application of Electrochemotherapy for Local Control

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
This case report describes an aggressive gingival extramedullary plasmacytoma (EMP) with regional lymph node metastasis in a 14‐year‐old cat. As complete surgical excision was unfeasible, three weekly electrochemotherapy (ECT) sessions using intravenous bleomycin were performed for local tumour control.
Seulgi Hwang, Hayoung Ryu, Dong‐In Jung, DoHyeon Yu, Kyu‐Woan Cho, Hyeona Bae   +5 more
wiley   +1 more source

Advances in Cytoplasmic Male Sterility in Sugar Beet from Mitochondrial Genome Structural Dynamics and Nuclear-Cytoplasmic Coordination. [PDF]

Int J Mol Sci
Zhong W, Zhang S, Gu X, Zhao Y, Wu Z, Liu D, Xing W.   +6 more
europepmc   +1 more source

Chronic, neutrophilic pericarditis with free‐floating intrapericardial mesothelial‐lined fibrous nodules in a cat

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 15‐year‐2‐month‐old, male, neutered domestic shorthair cat was presented for a 1‐week history of increased respiratory effort and declining appetite. Point‐of‐care ultrasound diagnosed tri‐cavitary effusion, and echocardiography revealed the presence of multiple free‐floating hyperechoic nodules within the pericardium.
Maximiliane Gabriele Sehn, Deepa Cavalli‐Sforza Guitart, Jonathan Williams, Victoria Lipscomb, Brogan Kim Atkinson   +4 more
wiley   +1 more source