Results 321 to 330 of about 279,378 (380)

Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine levels in juvenile idiopathic arthritis and its types. [PDF]

Rev Assoc Med Bras (1992)
Dogantan S, Yücel BB, Sayin SH, Taskin SN, Oyaci Y, Pehlivan S.   +5 more
europepmc   +1 more source

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Annual Review of Biochemistry, 2005
▪ Abstract  Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
Timothy H. Bestor, Mary G. Goll
openaire   +4 more sources

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Nature Biotechnology, 2022
Improved cytosine base editors are generated by phage-assisted evolution of a deoxyadenosine deaminase. Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base
, Nicholas Krasnow, Amber N Mcelroy
exaly   +2 more sources

Improved cytosine base editors generated from TadA variants

Nature Biotechnology, 2023
Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uracil repair.
Patricia R Feliciano, Amena Arif, Phil Grayson   +2 more
exaly   +2 more sources

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Nature Biotechnology, 2020
Cytosine base editors (CBEs) enable targeted C•G-to-T•A conversions in genomic DNA. Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide Cas9-independent off-target C•G-to-T•A mutation in mouse embryos and in rice ...
Jordan L Doman, Aditya Raguram, Gregory A Newby   +2 more
exaly   +2 more sources

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Science, 2017
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma   +2 more
exaly   +2 more sources

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Nature Biotechnology, 2022
, Haowei Meng, Yuting Guan
exaly   +2 more sources