Results 331 to 340 of about 279,378 (380)

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Science, 2019
Spotting off-targets from gene editing Unintended genomic modifications limit the potential therapeutic use of gene-editing tools. Available methods to find off-targets generally do not work in vivo or detect single-nucleotide changes.
Yidi Sun, Wu Wei, Tanglong Yuan
exaly   +2 more sources

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Nature Biotechnology, 2020
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR–Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that can ...
Julian Grünewald, Ronghao Zhou, Caleb A Lareau   +2 more
exaly   +2 more sources

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Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors

Nature Biotechnology, 2020
Xiangbing Meng, Yuan Zong, Jin-Long Qiu
exaly   +2 more sources

Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Nature Biotechnology, 2020
Geng Chen, Hongquan Geng, Xiufeng Pang
exaly   +2 more sources

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Nature Methods, 2020
Erwei Zuo, Yidi Sun, Tanglong Yuan
exaly   +2 more sources

The SPR Sensor Detecting Cytosine−Cytosine Mismatches

Journal of the American Chemical Society, 2003
We have synthesized the first surface plasmon resonance (SPR) sensor that detects cytosine-cytosine (C[bond]C) mismatches in duplex DNA by immobilizing aminonaphthyridine dimer on the gold surface. The ligand consisting of two 2-aminonaphthyridine chromophores and an alkyl linker connecting them strongly stabilized the C[bond]C mismatches regardless of
Kobori, A, Horie, S, Suda, H, Saito, I, Nakatani, K   +4 more
openaire   +3 more sources

Theoretical Study of Cytosine−Al, Cytosine−Cu and Cytosine−Ag (Neutral, Anionic and Cationic)

The Journal of Physical Chemistry A, 2008
The binding of cytosine to Al, Cu and Ag has been analyzed using the hybrid B3LYP density functional theory method. The three metals all have open shell electronic configuration, with only one unpaired valence electron. Thus it is possible to study the influence of electronic configuration on the stability of these systems.
Ana Martínez, Marco-Vinicio Vazquez
openaire   +3 more sources

Restricted rotation in crystalline cytosine and cytosine monohydrate

Transactions of the Faraday Society, 1970
The n.m.r. parameters T1 and T1ρ, the spin-lattice relaxation times in the laboratory- and rotating-frames, respectively, have been utilized to study the molecular motions that occur in polycrystalline samples of cytosine and cytosine hydrate in the range 130–293 K. The deuterated analogues have also been studied.
Judith Thomas, I. Adams, G. Parry Jones
openaire   +2 more sources

Inheritance of Cytosine Methylation

Journal of Cellular Physiology, 2016
There are numerous examples of parental transgenerational inheritance that is epigenetic. The informational molecules include RNA, chromatin modifications, and cytosine methylation. With advances in DNA sequencing technologies, the molecular and epigenetic mechanisms mediating these effects are now starting to be uncovered.
Charles Vinson, Sanjit Mukherjee, Desiree Tillo   +2 more
openaire   +3 more sources

Protonation of cytosine in DNA

Biopolymers, 1966
AbstractSpectrophotometric acid titrations of DNA samples of different GC content were performed at different wavelengths. From the acid titration profile and absorbance changes of deoxycytidine‐5′‐monophosphate and DNA the extent of protonated cytosine within the DNA double‐stranded molecule was estimated (pK 3.65 at 25°C. in 0.02M KCl).
H. Venner, Ch. Zimmer
openaire   +3 more sources