Results 101 to 110 of about 30,637 (206)

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, Volume 292, Issue 24, Page 6516-6532, December 2025.
DNA damage can slow or delay the cell cycle to allow for DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with damaged DNA, SOD1 restrains the activity of the phosphatase PP2a activity via oxidation of cysteine residues at PP2a's active site.
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Characterization of iNOS⁺ Neutrophil-like ring cell in tumor-bearing mice

Journal of Translational Medicine, 2012
Background Myeloid-derived Suppressor Cells (MDSC) have been identified as tumor-induced immature myeloid cells (IMC) with potent immune suppressive activity in cancer.
Virtuoso Lauren P, Harden Jamie L, Sotomayor Paula, Sigurdson Wade J, Yoshimura Fuminobu, Egilmez Nejat K, Minev Boris, Kilinc Mehmet O   +7 more
doaj   +1 more source

The impact of γ-irradiation on the induction of bystander killing by genetically engineered ovarian tumor cells: implications for clinical use [PDF]

, 2017
Background Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment.
Christmas, Stephen E, Zweiri, Jehad
core   +1 more source

A Simple and Efficient Method for Preparing Cell Slides and Staining without Using Cytocentrifuge and Cytoclips

International Journal of Cell Biology, 2015
Cell staining is a necessary and useful technique for visualizing cell morphology and structure under a microscope. This technique has been used in many areas such as cytology, hematology, oncology, histology, virology, serology, microbiology, cell ...
Xiaotang Hu, Verronika Laguerre, Daniel Packert, Alice Nakasone, Lynn Moscinski   +4 more
doaj   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu, A Kadioglu, A Nalbant, A Strasser, AD Badley, Andrea M. Mitchell, C Riccardi, CA Janeway Jr, CK Sung, D Zhou, David H. Dockrell, DH Dockrell, DH Dockrell, DH Dockrell, DR Cundell, EE McGrath, FK Swirski, Frank R. DeLeo, G Matute-Bello, Helen M. Marriott, HM Marriott, HM Marriott, I Nicoletti, J Warwick-Davies, JA Carrero, Julie A. Preston, K Beiter, K Kemp, K LeMessurier, KA Browne, KE Price, L Galluzzi, L Maggi, L Ziegler-Heitbrock, LA Kirkham, M Daigneault, M Lenardo, M Witzenrath, MA Barocchi, MA Bewley, Marc Daigneault, Martin A. Bewley, MJ Jedrzejas, Moira K. B. Whyte, N Olivares-Zavaleta, N Oyaizu, NV Serbina, PA Kiener, R Malley, RA Hirst, Robert C. Read, RS Hotchkiss, RS Hotchkiss, RS Hotchkiss, SE Weber, SJ Webster, SL Newman, T Mattern, T Takahashi, Thushan I. De Silva, Timothy J. Mitchell, WL Farrar, WP Hausdorff, YJ Lu, Z Zhang   +64 more
core   +4 more sources

Comparison of conventional smear and liquid-based cytology preparation in diagnosis of lung cancer by bronchial wash and transbronchial needle aspiration

Journal of Cytology, 2018
Introduction: Liquid-based cytology (LBC), initially developed for screening gynecologic specimens, is now being used in nongynecologic aspiration and exfoliative specimens.
Aasma Nalwa, Ritika Walia, Varsha Singh, Karan Madan, Sandeep Mathur, Venkateshwaran Iyer, Deepali Jain   +6 more
doaj   +1 more source

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. [PDF]

, 2001
Dystrophin-deficient muscles experience large reductions in expression of nitric oxide synthase (NOS), which suggests that NO deficiency may influence the dystrophic pathology.
Spencer, MJ, Tidball, JG, Wehling, M
core  

Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]

, 2018
Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio, Burclaff, Buzzelli, Caruso, Correa, Correa, Correa, Dai, Degterev, DeLyria, Ding, DiPaolo, DiPaolo, El-Omar, Ferlay, Fox, Ge, Harrington, Hervas-Stubbs, Howlett, Kolls, Landgren, Lennerz, Li, Liao, Machado, McHugh, Merchant, Mills, Moseley, Nam, Nguyen, Nguyen, Nguyen, Nguyen, Onishi, Park, Ramsey, Schumacher, Schwarzenberger, Stummvoll, Varga, Velin, Wada, Yamada, Yamaguchi, Zhang, Zhu   +47 more
core   +3 more sources

Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure [PDF]

, 2005
The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Caughey B, Fraser H, Huang F-P, Kapasi ZF, Meyer RK, Porter DD, Taylor DM, Wright SD, Wykes M, Xu S, Yamada N   +10 more
core   +2 more sources