Results 201 to 210 of about 871,555 (308)

CD147 regulates CD8⁺ T cell cytotoxic activity by facilitating phosphorylation and subsequent recruitment of proximal TCR signaling kinases. [PDF]

iScience
Shu T, Wang D, Wang H, Zou J, Qin H, Liang X, Cui H, He Q, Zhang Y, Jiang J.   +9 more
europepmc   +1 more source

The organ transplanted patient - immunological concepts and immunosuppression [PDF]

, 1991
Husberg, BS, Klintmalm, GBG, Starzl, TE
core  

Parallel 3D Bioprinting on SLIPS‐Microarrays

Advanced Functional Materials, EarlyView.
This work introduces the first truly parallel 3D bioprinting method, enabling both the simultaneous fabrication of hundreds of cell laden hydrogel 3D structures and their HTS in individual liquid compartments. By integrating Digital Light Processing (DLP) stereolithography with functional micropatterns, the platform decouples printing time from array ...
Julius von Padberg, Julian A. Serna, Maike Schliephake, Pavel A. Levkin   +3 more
wiley   +1 more source

QSAR machine learning-guided discovery of renieramycin right-half derivatives with cytotoxic activity against NSCLC cells. [PDF]

Sci Rep
Putra ID, Maitarad P, Yokoya M, Ei ZZ, Hotta D, Shi L, Rungrotmongkol T, Chanvorachote P.   +7 more
europepmc   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Chemical Characterization, Evaluation of Antimicrobial Potential, and Cytotoxic Activity of <i>Thuja occidentalis</i> L. and <i>Myrtus communis</i> L. Essential Oils for Topical Applications. [PDF]

Molecules
Dănilă E, Marinas IC, Gaboreanu MD, Neacșu VA, Titorencu I, Marin MM, Kaya DA, Çeliktaş N, Albu Kaya M, Țuțuianu R.   +9 more
europepmc   +1 more source

Photo‐Controlled Antibacterial Drug Release From DASA‐Coated Silica Particles for Improved Treatment of Wound Infections

Advanced Functional Materials, EarlyView.
Synthesis and characterization of light‐responsive donor–acceptor Stenhouse adducts (DASA)‐coated chlorhexidine‐loaded silica nanoparticles. Such a controllable drug‐delivery system enables the release of the antimicrobial drug on demand and in consecutive cycles, thereby maintaining the concentration within the therapeutic window.
Michèle Clerc, Flavia Zuber, Lea Oberhänsli, Yvonne Elbs‐Glatz, Maria M. Miguel, Vera M. Kissling, Qun Ren, Markus Rottmar, Luciano F. Boesel, Giorgia Giovannini   +9 more
wiley   +1 more source

Synthesis and Cytotoxic Activity of a New Family of α-Hydroxyphosphonates with the Benzothiophene Scaffold. [PDF]

Pharmaceuticals (Basel)
Milen M, John TM, Kis AS, Garádi Z, Szalai Z, Takács A, Kőhidai L, Karaghiosoff K, Keglevich G.   +8 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source