Results 241 to 250 of about 871,555 (308)

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Colombian cyanobacteria with cytotoxic activity in cancer cell lines. [PDF]

Heliyon
Darwich-Cedeño MT, Montenegro-Ruiz LC, Reis M, Vasconcelos V.   +3 more
europepmc   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Design, synthesis, <i>in vitro</i> cytotoxic activity, and <i>in silico</i> studies of symmetrical chlorophenylamino-<i>s</i>-triazine derivatives. [PDF]

RSC Adv
Canh Pham E, Nguyen ST, Thi Le KA, Thi Hong Do T, Truong TN.   +4 more
europepmc   +1 more source

Generation of virus specific cytotoxic T cells in vitro [PDF]

, 1979
Greber, D., Koszinowski, Ulrich H., Neuschaefer-Rube, I.   +2 more
core  

Fluorescent Nanosensor for Indole‐3‐Propionic Acid Detection in Gut Health Monitoring

Advanced Healthcare Materials, EarlyView.
This work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Mervin Chun‐Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez‐Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S. Strano   +15 more
wiley   +1 more source

Facilitation of natural killer T-cell cytotoxic activity in uterine sarcoma via the <i>CKS2-PI3K-AKT-MICA</i> axis. [PDF]

Transl Cancer Res
Du Y, Lan T, Liu M, Wu W, Ma J.
europepmc   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells. [PDF]

Pharmaceuticals (Basel)
Reina M, Ariza X, Serra D, Garcia J, Herrero L.   +4 more
europepmc   +1 more source

New Insights into the Metabolic Profile and Cytotoxic Activity of <i>Kigelia africana</i> Stem Bark. [PDF]

Molecules
Zheleva-Dimitrova D, Mihaylova R, Nikolova M, Singh N, Konstantinov S.   +4 more
europepmc   +1 more source