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[41] Cytotoxicity of chloramines
1986Publisher Summary This chapter describes the cytotoxicity of chloramines. The binding of ligands to the membrane-surface receptors of neutrophilic leukocytes stimulates the reduction of oxygen (O 2 ) to superoxide (O 2 – ) and the secretion of cytoplasmic granule components including myeloperoxidase into the intracellular phagolysosome compartment ...
Edwin L. Thomas +2 more
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Specific tumoricidal activity of cytotoxic macrophages and cytotoxic lymphocytes
Cancer Immunology, Immunotherapy, 1986The antitumor potency and specificity of syngeneic immune peritoneal exudate cells were tested. Groups of DBA/2 mice were immunized against syngeneic SL2 tumor cells. Then 6 days after the last immunization the antitumor potency, and the specificity of the immunization reaction was tested by injecting groups of the immunized mice with 10(3) to 5 X 10(7)
Hub F.J. Dullens +5 more
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Metoclopramide Inhibits the Cytotoxicity of Cisplatin and Enhances the Cytotoxicity of Epirubicin
Pharmacology & Toxicology, 1995Abstract: During cancer treatment, the use of antiemetics are often needed due to induction of nausea and vomiting by antineoplastic drugs. Some antiemetics have however been afflicted with cytotoxic effects during chemotherapy. The influence of the commonly used antiemetic metoclopramide on the cytotoxicity of epirubicin and cisplatin was tested on ...
Kjell Grankvist +2 more
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New cytotoxics and non-cytotoxics in epithelial ovarian cancer
International Journal of Gynecological Cancer, 2000Several new cytotoxic agents with activity in relapsed ovarian cancer are being combined with paclitaxel plus platinum as the first step to assess their impact in randomized trials against the standard treatment. These include topotecan, gemcitabine, epirubicin, and liposomal doxorubicin. Because of overlapping toxicities, there have been challenges in
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Subpopulations of Cytotoxic T Lymphocytes with Different Cytotoxic Mechanisms
1993Subpopulations of T lymphocytes have been identified based on (1) expression of CD4 or CD8 accessory molecules on the cell surface [CD4+ cells generally recognize antigen (Ag) presented in the context of class II major histocompatibility complex (MHC) molecules, while CD8+ cells generally recognize Ag presented in the context of class I MHC molecules],
Maureen McKisic +2 more
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Cytotoxicity of Methacrylonitrile
Bulletin of Environmental Contamination and Toxicology, 1997R. Nalini +3 more
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ANTIMETABOLITES AND CYTOTOXIC DRUGS
Dermatologic Clinics, 2001Mycophenolic mofetil, azathioprine, thioguanine, methotrexate, and cyclophosphamide were initially used for the treatment of malignancies. Because of their immunosuppressive activity, the range of diseases responsive to these medications has expanded to include various autoimmune-related diseases.
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T‐Cell Cytotoxicity and Amplification of the Cytotoxic Reaction by Macrophages
Immunological Reviews, 1973H. Fischer, M. L. Lohmann-Matthes
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Cytotoxicity as a Mechanism of Carcinogenesis
1985Some of our previous results had shown that certain relatively weak carcinogens induced DNA single-strand breaks in rat hepatocytes but only with concomitant cytotoxicity. Stronger carcinogens usually induced breaks at relatively nontoxic concentrations.
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