Results 201 to 210 of about 23,652 (213)

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Current therapeutics for sclerotic and fibrotic manifestations of chronic graft-versus-host disease. [PDF]

Bone Marrow Transplant
Choe H, DeFilipp Z.
europepmc   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

A Case Report of Advanced Pulmonary Adenocarcinoma in a Dog Managed with Chemotherapy and Cytokine-Based Immunotherapy. [PDF]

Animals (Basel)
Yeon KD, Seo JH, Kim JH.
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4⁺ T cells in humans. [PDF]

Sci Adv
Kar R, Sinha S, Khatun Z, Sharma A, Patil VS.   +4 more
europepmc   +1 more source

CD16A Shedding Regulates Innate Cell Engager-Induced Serial Killing by Natural Killer Cells. [PDF]

Eur J Immunol
Zambarda C, Guldevall K, Breunig C, Toullec D, Sandoz PA, Carannante V, Xu S, Ross P, Kuhnigk K, Sandström N, Fontana J, Wingert S, Pinto S, Knoch J, Hussain A, Wagner AK, Pahl J, Alici E, Koch J, Önfelt B.   +19 more
europepmc   +1 more source

Advances in Lipid-Polymer Hybrid Nanoparticles: Design Strategies, Functionalization, Oncological and Non-Oncological Clinical Prospects. [PDF]

Pharmaceuticals (Basel)
Jacob S, Varkey NR, Boddu SHS, Gorain B, Rao R, Nair AB.   +5 more
europepmc   +1 more source

Long-term Graft and Patient Survival in Kidney Transplant Recipients With High Levels of Preformed DSAs (MFI > 3000): A Propensity Score-matched Analysis. [PDF]

Transplant Direct
Debiais-Deschamps C, Amrouche L, Rabant M, Duong Van Huyen JP, Burger C, Roger C, Le Stang MB, Troger A, Leon J, Martinez F, Sberro-Soussan R, Scemla A, Peraldi MN, Zuber J, Anglicheau D, Legendre C, Aubert O.   +16 more
europepmc   +1 more source

Coexistence of bullous pemphigoid, intrahepatic cholangiocarcinoma, and alopecia areata: a case report of multifactorial autoimmunity in a surgical context. [PDF]

Front Immunol
Li S, Wang Y, Yang D.
europepmc   +1 more source