Results 201 to 210 of about 22,215 (211)

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Exploring the Effects of Sweet Potato Leaves on Skin Health-From Antimicrobial to Immunomodulator. [PDF]

Molecules
Machado M, Silva S, Pintado M, Costa EM.
europepmc   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Memory-like Natural Killer Cell and CD19 Antibody-Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia. [PDF]

Cancer Immunol Res
Eskandarian Z, Hauch R, Schuster S, Winterberg D, Grabellus H, Imelmann C, Heitmann AL, Goos M, Rudloff K, Strauss J, Wolters-Eisfeld G, Nollau P, Klausz K, Schüller U, Peipp M, Spohn M, Horstmann MA.   +16 more
europepmc   +1 more source

Trained autologous cytotoxic T-cells derived from PBMCs or splenocytes for immunotherapy of neuroblastoma. [PDF]

Front Immunol
Wu X, Basu M, Wright SL, Li S, Petrosyan M, Nelson MV, Halpern AI, Shea D, Yarmakovich M, Sandler AD.   +9 more
europepmc   +1 more source

PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design. [PDF]

Immunol Res
Lin Z, Zhao H, Lin H, Song L, Tian X, Choo SW.   +5 more
europepmc   +1 more source

Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines. [PDF]

Front Immunol
González Muñoz C, Álvarez Arzola R, Calvo Pérez A, Frometa Campanón MC, Hernández Casaña P, Fernández-Calienes Valdés A, Lorenzo-Luaces P, Mazorra Herrera Z, Crombet Ramos T, Labrada Mon M.   +9 more
europepmc   +1 more source

Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies. [PDF]

Nat Commun
Damei I, Caidi A, Auclin E, Adam J, Mella S, Hasan M, Tartour E, Robert C, Corgnac S, Mami-Chouaib F.   +9 more
europepmc   +1 more source

Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis. [PDF]

J Immunol
Björk E, Israelsson P, Nagaev I, Nagaeva O, Lundin E, Ottander U, Mincheva-Nilsson L.   +6 more
europepmc   +1 more source

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[The lymphocyte cytotoxicity test in tumor immunology (author's transl)].

Klinische Wochenschrift, 1975
The cytotoxic action of lymphocytes on cancer cells in vitro indicates sensitization of the patient against his own tumor. The technical difficulities of this test and possibilities of standardization and simplifying the procedure are discussed. Critical steps are isolation of lymphocytes and culturing target cells without loosing their specific ...
openaire   +4 more sources