Results 21 to 30 of about 23,652 (213)

Magnetofection potentiates gene delivery to cultured endothelial cells [PDF]

, 2003
Modification of cellular functions by overexpression of genes is increasingly practised for research of signalling pathways, but restricted by limitations of low efficiency. We investigated whether the novel technique of magnetofection (MF) could enhance
Gloe, Torsten, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Sohn, Hae-Young   +4 more
core   +1 more source

In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]

, 2019
Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi, A Cerwenka, A Hadji, A Orbach, AP Costa-Pereira, Baryshnikov AYu, C Fionda, H Cho, HA Elrod, I Viard-Leveugle, J Sträter, J Wu, JC Symes, K Yamamoto, L Boldrini, L Galligan, L Siena, M Christgen, M Mottolese, M Müller, M Todaro, M Villa-Morales, MA Park, ME Peter, N Gordon, O Micheau, PB Carvalho-Neto de, RW McGilvray, S Yang, V Almendro, WM Liu, Y Hirooka, Y Kimura   +32 more
core   +2 more sources

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Efeitos citotóxicos e genotóxicos das ligas de solda de prata em ortodontia: revisão sistemática [PDF]

, 2015
Foi realizada uma revisão sistemática dos efeitos citotóxicos e genotóxicos das ligas de solda de prata em Ortodontia. Para tanto, foi efetuada uma busca sistemática nas bases de dados PubMed, EMBASE, Web of Science e Biblioteca Cochrane.
Garcia, Renato Dalla Porta
core  

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]

, 2009
Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora, A Scheffold, AF Setiadi, AM Pearse, Ariberto Fassati, B Comin-Anduix, B Kavanagh, B Muller-Hilke, C Murgia, CA Rebbeck, CC Chang, CL Yauk, CM Gonzalez, CM Koebel, CY Lin, D Cohen, D Cohen, D Cohen, D Cohen, E Ambrosino, E Klein, E Mozos, ED Carosella, ED Carosella, EK Geissler, FR Depontieu, G Willimsky, GD Snell, GP Dunn, GP Dunn, GP Dunn, H Ikeda, H McCallum, H Wajant, HV Siddle, HV Siddle, I Kryczek, J Galon, J Hori, J Perez, J Zhou, K Kretschmer, K Masuda, K Milne, KJ Malmberg, KL Wright, L Tian, L Vago, L Yip, M Bleakley, M Campoli, M Gerloni, M Mammolenti, M Mehling, M Novinski, M Pierobon, M Shackleton, M Thornley, MA Cheever, MN Scherer, N Mitchison, N Schwinn, N. Avrion Mitchison, NA Mitchison, NM Moutsopoulos, P Jimenez, PC Chou, R Mendez, R Mendez, R Uppaluri, S Lob, S Verheyden, SM Kang, SR Choudhury, T Akagi, T Cabrera, T Isoda, T Marchal, T Rodriguez, TJ Yang, TJ Yang, W Reith, YC Chang, YW Hsiao, YW Hsiao   +84 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source