Results 101 to 110 of about 21,236 (243)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Journal of Behçet Uz Children's HospitalObjective: We aim to show whether endoscopic, histopathological and precancerous findings in childhood Helicobacter pylori (H. pylori) infection are associated with some changes in the host immune system and some virulence factors of the bacteria.
Ayşegül Cebe Tok +5 more
doaj +1 more source
Cytotoxin-Associated Gene A-Negative Helicobacter pylori Promotes Gastric Mucosal CX3CR1+CD4+ Effector Memory T Cell Recruitment in Mice. [PDF]
Front Microbiol, 2022 Sun H +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2016 Background: Helicobacter pylori (H. pylori) is known as the main pathogen which causes infection in human’s stomach. There are three strains of H. pylori, which are type I, intermediate, and type II strains of H. pylori.
Burhana Mawarasti +2 more
doaj
The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria
Gastroenterology Research and Practice, 2013 Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients.
Yi-Chun Chiu +9 more
doaj +1 more source
Cytotoxin-Associated Gene A-Positive Helicobacter pylori Promotes Autophagy in Colon Cancer Cells by Inhibiting miR-125b-5p. [PDF]
Can J Infect Dis Med Microbiol, 2021 Zhong X, Chen O, Zhou T, Lü M, Wan J.
europepmc +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source