Results 1 to 10 of about 33,889 (177)
Frontiers in Cardiovascular Medicine, 2022 BackgroundHelicobacter pylori (H. pylori) infection increases the risk for atherosclerosis, and ROS are critical to endothelial dysfunction and atherosclerosis. CagA is a major H. pylori virulence factor associated with atherosclerosis. The present study
Hao Wu, Linfang Zhang, Qiang Zhu
exaly +3 more sources
Cell Reports, 2017 Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the East Asian CagA-specific EPIYA-D segment binds to the N-SH2 domain of pro-oncogenic SHP2 ...
Masanori Hatakeyama +2 more
exaly +3 more sources
Frontiers in Cellular and Infection Microbiology, 2017 Cytotoxin-associated-gene A (CagA) of Helicobacter pylori (H. pylori) is a virulence factor that plays critical roles in H. pylori-induced gastric inflammation.
Yuan Zhuang, Xu-Hu Mao, Qiao Bin
exaly +3 more sources
Molecular docking of a set of flavonoid compounds with Helicobacter pylori virulence factors CagA and VacA [PDF]
Journal of HerbMed Pharmacology, 2020 Introduction: Cytotoxin associated gene A (CagA) and vacuolating cytotoxin A (VacA) proteins are the main Helicobacter pylori virulence factors. These toxins are associated with severe gastric diseases.
Mohamed Reda Jouimyi +7 more
doaj +1 more source
Journal of Contemporary Medicine, 2021 Aim: Potent combined and long-term antithrombotic therapies that predispose to gastric injury are the mainstay of treatment in acute coronary syndromes (ACS). Severe chronic gastric mucosal inflammation due to the Helicobacter Pylori (H.
Barış Şensoy, Nur Ozer Sensoy
doaj +1 more source
THE H. PYLORI-RELATED VIRULENCE FACTOR CAGA INFLUENCES THE EXPRESSION OF CHEMOKINES CXCL10, CCL17, CCL20, CCL22, AND THEIR RECEPTORS BY PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PEPTIC ULCER PATIENTS [PDF]
Arquivos de Gastroenterologia, 2020 BACKGROUND: During the Helicobacter pylori (HP) infection, the infiltration of the leukocytes into stomach mucosa is directed by locally produced chemokines that play a decisive role in infection outcome.
Shila JALALPOUR +5 more
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Advanced Biomedical Research, 2022 Background: This study aimed to determine the current EPIYA motifs of the cagA gene in Helicobacter pylori isolates from patients with gastric disorders, and evaluate the association between these patterns and the clinical outcome of H.
Fatemeh Estaji +4 more
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Helicobacter pylori CagA EPIYA Motif Variations Affect Metabolic Activity in B Cells
Toxins, 2021 Background: Helicobacter pylori (Hp) colonizes the human stomach and can induce gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. Clinical observations suggest a role for the Hp virulence factor cytotoxin-associated gene A (CagA) in ...
Sebastian Diechler +4 more
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Gut Microbes, 2022 Helicobacter pylori is the major risk factor for gastric cancer. H. pylori harboring the type IV secretion system (T4SS) and its effector CagA encoded on the cag pathogenicity Island (cagPAI) increases the risk. H. pylori PMSS1 has a multi-cagA genotype,
Sungil Jang +4 more
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Helicobacter pylori CagA disrupts epithelial patterning by activating myosin light chain. [PDF]
PLoS ONE, 2011 Helicobacter pylori infection is a leading cause of ulcers and gastric cancer. We show that expression of the H. pylori virulence factor CagA in a model Drosophila melanogaster epithelium induces morphological disruptions including ectopic furrowing.
Jonathan B Muyskens, Karen Guillemin
doaj +1 more source