Results 31 to 40 of about 33,889 (177)
Journal of Pure and Applied MicrobiologyHelicobacter pylori’s type IV secretion system (T4SS) is a key virulence determinant, mediating the delivery of effector proteins such as cytotoxin-associated gene A (CagA) into host epithelial cells.
Swagata Sain +3 more
doaj +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, 2021 Objectives. To investigate the effects of cytotoxin-associated gene A- (CagA-) positive Helicobacter pylori on proliferation, invasion, autophagy, and expression of miR-125b-5p in colon cancer cells. Methods.
Xiaolin Zhong +4 more
doaj +1 more source
A Novel Inhibitory Domain of Helicobacter pylori Protein CagA Reduces CagA Effects on Host Cell Biology [PDF]
Journal of Biological Chemistry, 2011 The Helicobacter pylori protein CagA (cytotoxin-associated gene A) is associated with an increased risk for gastric cancer formation. After attachment to epithelial cells, the bacteria inject CagA via a type IV secretion apparatus into host cells, where it exerts its biological activity.
Pelz, C. +4 more
openaire +3 more sources
Proceedings of CAGA24: The Conference of AG Animation 2024Welcome to the Proceedings of the 7thConference of AG Animation 2024 (CAGA), hosted by The AnimationWorkshop, VIA University College in Viborg from September 10thto 11th, 2024. CAGA 2024 served as a nexusfor scholarly discourse, professional exchange, and creative exploration, uniting academics, industry practitioners,curators, and enthusiasts within ...
Holmsgaard Fyhn, Bue +5 more
openaire +3 more sources
The Egyptian Journal of Internal Medicine, 2019 Introduction and aims Gastric cancer is currently the second most common cause of cancer-related death in the world and the fifth most common cancer and the fourth leading cause of cancer-related death in Europe.
Ahmed N El Mazny +3 more
doaj +1 more source
International Journal of Preventive Medicine, 2020 Background: The correlation of Helicobacter pylori infection with gastritis, peptic ulcer, and gastric cancer has been proven. The aim of this study was to determine the effects of cagA+and cagA−genotypes of H.
Saeed Salavati +4 more
doaj +1 more source
Helicobacter Pylori CagA and Gastric Carcinogenesis
Asian Pacific Journal of Cancer Prevention, 2012 This study aimed to demonstrate the tyrosine phosphorylation motif (TPM) and 3' region structure of the Helicobacter pylori CagA gene as well as its SHP-2 binding activity in AGS cells and relation to gastric carcinogenesis.Sixteen clinical isolate H.
Ri-Nan, Zheng +2 more
openaire +3 more sources
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari +3 more
wiley +1 more source
Virulence determinants and genotypes of Helicobacter pylori clinical isolates
Журнал микробиологии, эпидемиологии и иммунобиологии, 2023 Background. H. pylori is the principal causative agent of gastroduodenal disorders in humans. The development and severity of lesions in infected individuals depend on the virulence of H. pylori strains.
Alena V. Svarval +2 more
doaj +1 more source