Results 41 to 50 of about 33,889 (177)

Cholesterol Depletion ReducesHelicobacter pyloriCagA Translocation and CagA-Induced Responses in AGS Cells [PDF]

Infection and Immunity, 2008
ABSTRACTInfection withHelicobacter pylori cagA-positive strains is associated with gastritis, ulcerations, and gastric cancer. CagA is translocated into infected epithelial cells by a type IV secretion system and can be tyrosine phosphorylated, inducing signal transduction and motogenic responses in epithelial cells.
Chih-Ho, Lai, Yun-Chieh, Chang, Shin-Yi, Du, Hung-Jung, Wang, Chun-Hsien, Kuo, Shih-Hua, Fang, Hua-Wen, Fu, Hui-Hao, Lin, Ann-Shyn, Chiang, Wen-Ching, Wang   +9 more
openaire   +2 more sources

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

CagA Effector Protein in Helicobacter pylori-Infected Human Gastric Epithelium in Vivo: From Bacterial Core and Adhesion/Injection Clusters to Host Cell Proteasome-Rich Cytosol

Toxins, 2019
A key role in the carcinogenic action of Helicobacter pylori is played by the effector protein CagA, the first identified oncoprotein of the bacterial world.
Vittorio Necchi, Vittorio Ricci, Patrizia Sommi, Enrico Solcia   +3 more
doaj   +1 more source

Analysis of Helicobacter pylori cagA Promoter Elements Required for Salt-Induced Upregulation of CagA Expression [PDF]

Infection and Immunity, 2012
ABSTRACT Helicobacter pylori infection and consumption of a high-salt diet are each associated with an increased risk for the development of gastric cancer. To investigate potential synergism between these factors, we used a global proteomic approach to analyze H. pylori
John T, Loh, David B, Friedman, M Blanca, Piazuelo, Luis E, Bravo, Keith T, Wilson, Richard M, Peek, Pelayo, Correa, Timothy L, Cover   +7 more
openaire   +2 more sources

Differences in the Gastric Microbiotas of Neighboring Populations With Divergent Risks of Gastric Cancer

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Although Helicobacter pylori plays a central role in gastric cancer (GC), other microorganisms involved in gastric dysbiosis may also impact carcinogenesis. We aimed to characterize gastric dysbiosis and its role in the transition from non‐atrophic gastritis (NAG) to gastric premalignant lesions (GPLs) in two populations from Nariño,
Juan Camilo Caguazango, Karla Vinasco, Isidora Simovic, Yomaira Yépez Caicedo, Marino Coral Bedoya, Nadeem O. Kaakoush, Natalia Castaño‐Rodríguez   +6 more
wiley   +1 more source

Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA‐specific antibody [PDF]

Pathology International, 2008
The cytotoxin‐associated antigen A (CagA) of Helicobacter pylori prevalent in East Asian countries, where the mortality rate due to gastric cancer is high, has been reported to be structurally different from that in Western countries, where the gastric cancer mortality rate is relatively low. Based on the structural features of the EPIYA motifs located
Ryoko, Kanada, Tomohisa, Uchida, Yoshiyuki, Tsukamoto, Lam Tung, Nguyen, Naoki, Hijiya, Keiko, Matsuura, Masaaki, Kodama, Tadayoshi, Okimoto, Kazunari, Murakami, Toshio, Fujioka, Shigetaka, Yanagisawa, Masatsugu, Moriyama   +11 more
openaire   +2 more sources

Burden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case‐Cohort Study

International Journal of Cancer, Volume 159, Issue 5, Page 1282-1295, 1 September 2026.
While several oncogenic pathogens cause site‐specific cancers, uncertainties remain about many other chronic infections and combined pathogen effects, especially in non‐Western populations. Using a large case–cohort study nested within the China Kadoorie Biobank, the authors found that co‐infection was common, with a mean of 10 pathogens per individual.
Ling Yang, Jonathan Clarke, Lea Kröller, Christiana Kartsonaki, Hannah Fry, Rima Jeske, Andrew Gordon, Sarah Clark, Michael Hill, Daniel Avery, Yiping Chen, Huaidong Du, Jun Lv, Dianjianyi Sun, Canqing Yu, Liming Li, Iona Y. Millwood, Tim Waterboer, Zhengming Chen, on behalf of the China Kadoorie Biobank Collaborative Group, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Liming Li, Jun Lv, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Yuting Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Yiping Chen, Zhengming Chen, Jonathan Clarke, Robert Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Dan Schmidt, Becky Stevens, Iain Turnbull, Robin Walters, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Dan Hu, Xiaoyan Zheng, Yujie Wang, Wei Sun, Shichun Yan, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Tingting Ou, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Yan Xu, Jinyi Zhou, Ran Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Yan Lu, Yujie Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, Ge Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Mingqiang Yuan, Ling Wang, Xiaofang Chen, Zhaodong Wang, Qiang Sun, Yang Lin, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, Li Gao, Shaofang Li, Tianfang Xing, Wei Tang, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Hao Xu, Yuan Cao, Kaixu Xie, Lingli Chen, Xiaomei Tu, Junlong Pan, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Yin, Xian Xie, Jing Wang, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Chan Qu, li Deng, Qili Jiang, Yanling Chen   +212 more
wiley   +1 more source

Helicobacter pylori cagAPromoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion [PDF]

Journal of Infectious Diseases, 2015
Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally ...
Rui M, Ferreira, Ines, Pinto-Ribeiro, Xiaogang, Wen, Ricardo, Marcos-Pinto, Mário, Dinis-Ribeiro, Fátima, Carneiro, Ceu, Figueiredo   +6 more
openaire   +2 more sources

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Antibacterial Effects of Disulfiram in Helicobacter pylori

Infection and Drug Resistance, 2021
Tomomi Kobatake,1 Keiki Ogino,2 Hiroyuki Sakae,3 Kazuyoshi Gotoh,4 Akari Watanabe,5 Osamu Matsushita,4 Hiroyuki Okada,3 Kenji Yokota1 1Graduate School of Health Science Okayama University, Okayama, 700-8558, Japan; 2Department of Environmental Medicine ...
Kobatake T, Ogino K, Sakae H, Gotoh K, Watanabe A, Matsushita O, Okada H, Yokota K   +7 more
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