Results 41 to 50 of about 279,754 (316)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Nazwy obcych realiów w dziewiętnastowiecznym czeskim przekładzie „Narzeczonej z Abydos” Lorda Byrona

Acta Universitatis Wratislaviensis. Slavica Wratislaviensia
Článek se zabývá popisem a analýzou názvů cizích reálií vyskytujících se v českém překladu Nevěsty z Abydu od Lorda Byrona. V tomto literárním díle autor zahrnul mnoho jmen – vlastních i obecných – spojených s orientálním světem,
Mateusz Wiśniewski
doaj   +1 more source

“The Meaning of His Life Was Work”: The Construction of Identities in the Oral Narratives of Older Czech Men

Gender Studies, 2016
This article explores the ways in which older Czech men construct their masculine identities. Profiting from the personal memories of individuals who witnessed dramatic social changes in 20th century Czechoslovakia, the study draws on eight oral ...
Slabáková Radmila Švaříčková
doaj   +1 more source

Pozice nespisovných variet ve stylu nové české literatury

Stylistyka, 2020
The tendency to operate freely with devices of all language varieties and with characteristic practices of various functional styles is one of the significant features of the literary style.
Peter Mareš
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Anthroponyms and Toponyms in the Memorial Inscriptions at Cemeteries of National Minorities in Northern Bosnia and Herzegovina

Вопросы ономастики
The article examines the anthroponyms and toponyms found on gravestone inscriptions at cemeteries in the areas of concentrated settlement of national minorities in northern Bosnia and Herzegovina — namely, Ukrainians, Poles, Czechs, and Italians.
Gleb Petrovich Pilipenko, Sergej Aleksandrovich Borisov   +1 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Parallel corpus in analysing Czech spoken expressions and their equivalents in English, French, and Polish [PDF]

Linguistica Pragensia
This paper uses corpus data to analyse spoken expressions and discourse markers in Czech, applying these findings to corpus-based exercises for learners of Czech as a foreign language.
Adrian Jan Zasina
doaj   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source