Results 71 to 80 of about 833,670 (244)

Form and Functions of Intra-Urban Territories in Late Medieval and Early Modern Brussels (15th-16th centuries) [PDF]

open access: yes, 2008
This paper focuses on the spatial analysis of (some specific) intra-urban territories which existed in late medieval and early modern Brussels (Belgium).
Vannieuwenhuyze, Bram
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Les murs, le guet et la communauté : la construction d'un système défensif [PDF]

open access: yes, 2007
Il s'agit du dernier article du dossier coordonné par le même auteur, sous le titre "Des hommes et des murs. Pour une approche de la mise en défense des communautés dans le Sud-Ouest à la fin du Moyen Âge.
FERRAND, Guilhem
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

The DR3 Milky Way Rotation Curve within the Framework of General Relativity Without Dark Matter

open access: yesReports in Advances of Physical Sciences
The GAIA DR3 measurement campaign has produced a MW rotation curve with significantly improved accuracy compared with previous campaigns. In 2023, several authors presented accurate rotation curves calculated from these measurements, within the framework
Michel Canac
doaj   +1 more source

Ebranler la marge dan Moi, Tituba sorcière... noire de Salem (1986) et Memorial de Maria Moura (1992) de Rachel de Queiroz

open access: yesPoligramas, 2016
Dans un effort de comparaison de Yo, Tituba la bruja negra de Salem (1986) de Maryse Condé et de Memorial de María Moura (1992) de Rachel de Queiroz, cet article veut montrer de quelle façon ces auteurs envisagent la dichotomie entre la marge et le ...
Julie Brugier
doaj   +1 more source

What drives the market value of firms in the Defense industry ? [PDF]

open access: yes
This paper investigates the relative importance of different types of news in driving significant stock price changes of firms in the defense industry. We implement a systematic event study with a sample of the 58 largest publicly listed companies in the
Gunther Capelle-Blancard   +1 more
core  

Defending Victims of Domestic Abuse who Kill : A Perspective from English Law [PDF]

open access: yes, 2007
La « provocation cumulative » désigne les instances de mauvais traitements, pendant une période prolongée, d’une personne par une autre et qui se terminent par le meurtre de l’auteur par la victime d’abus.
Mousourakis, George
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

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