Results 91 to 100 of about 3,688,606 (250)

Déchets plastiques et dégradation de l’environnement dans la ville de Boundiali [PDF]

Revue de Géographie Tropicale et d’Environnement
De nombreuses études de caractérisation des déchets plastiques dans les villes de la Côte d’Ivoire montrent qu’une part de plus en plus importante de ces déchets est par nature potentiellement recyclable.
Sindou Amadou KAMAGATÉ, Kadjo Jean Claude KASSI, Losseni CISSÉ
doaj  

Impact des activités touristiques en forêt de Fontainebleau : de la dégradation à la restauration

VertigO, 2017
La forêt de Fontainebleau connait depuis le XIXe siècle une fréquentation touristique importante grâce à sa proximité avec la capitale et à sa diversité paysagère qui a attiré autant les peintres de Barbizon que les parisiens avides de plein air.
Micheline Hotyat
doaj   +1 more source

Genetic compensation triggered by mutant mRNA degradation

Nature, 2019
Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation,
Mohamed A. El-Brolosy, Zacharias Kontarakis, Andrea Rossi, C. Kuenne, S. Günther, Nana Fukuda, Khrievono Kikhi, Giulia L. M. Boezio, Carter M. Takacs, S. Lai, R. Fukuda, C. Gerri, Antonio J. Giráldez, D. Stainier   +13 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Scandales politiques et corruption en Argentine. Dénonciation publique et dégradation morale

Sociologies, 2017
This article aims at analyzing political scandals as a cornerstone of 1990s corruption in Argentina drawing on the perspective of public problems. First, it presents a statistical review of the political scandals of the decade.
Sebastián Pereyra
doaj  

Dégradation du couvert végétal des sites reboisés de Walia Hadjaraï et Ngonba dans le 9e arrondissement de la ville de N’Djaména-Tchad [PDF]

Pensées Genre, Penser Autrement
Cette étude analyse la dégradation du couvert végétal des sites reboisés de Walia Hadjarai et Ngonba, dans le 9ème arrondissement de N’Djamena. Malgré les programmes de reboisement mis en place depuis les années 1970, ces sites connaissent une régression
ALLAHINGAR Kadre
doaj   +1 more source

Plastics: Environmental and Biotechnological Perspectives on Microbial Degradation

Applied and Environmental Microbiology, 2019
Plastics are widely used in the global economy, and each year, at least 350 to 400 million tons are being produced. Due to poor recycling and low circular use, millions of tons accumulate annually in terrestrial or marine environments.
Dominik Danso, J. Chow, W. Streit
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source