Results 181 to 190 of about 29,438 (196)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Exploring Patient Involvement in Treatment Decision-Making for Diabetic Retinopathy: A COM-B Model-Based Cross-Sectional Survey. [PDF]

Patient Prefer Adherence
Xu L, Zhang H, Shen Y, Pu J, Wu Q, Chen L.   +5 more
europepmc   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Study Protocol of a Korean Patient-Centered Shared Decision-Making Model for Management of Severe Knee Osteoarthritis: A Multicenter Pragmatic Clinical Trial (K-SDM-KOA). [PDF]

J Korean Med Sci
Choi BS, Seo S, Chang MJ, Kim JI, Kim SH, Lee DW, Ro DH, Choi H, Han HS.   +8 more
europepmc   +1 more source

Can the Development of Orphan Drugs Include Wider Patient Engagement? A Citizens' Jury to Explore a Promissory Notion. [PDF]

Health Expect
Frost J, Widening Engagement Patient Advisory Group, Mandizha J, van den Dungen C, Asare L, Pope C.   +5 more
europepmc   +1 more source

Building the Iowa Data Drive: a participatory approach to developing early childhood indicators for state and local policymaking. [PDF]

Int J Popul Data Sci
Rouse H, Zanti S, Kim H, Dorius C, Abraham T, Chighladze G.   +5 more
europepmc   +1 more source

Less is more. Exploring opportunities and challenges of digital crowdsourcing for political parties. [PDF]

Open Res Eur
Nasi F.
europepmc   +1 more source

Sleep problems, decision-making, and suicide attempts during adolescence: a longitudinal birth cohort study. [PDF]

Sleep Adv
Pawley M, Morales-Muñoz I, Bagshaw AP, Tang NKY.   +3 more
europepmc   +1 more source

Choice-Induced Preference Change under a Sequential Sampling Model Framework

Lee DG, Pezzulo G.
europepmc   +1 more source