Results 111 to 120 of about 798,630 (244)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A

Journal of Cachexia, Sarcopenia and Muscle
Background Sepsis survivors often experience sustained muscle weakness, leading to physical disability, with no pharmacological treatments available.
Alexandre Pierre, Raphael Favory, Benoit Brassart, Claire Bourel, Raphael Romien, Sylvain Normandin, Arthur Dubech, Claire Vincent, Jeremy Lemaire, Gaelle Grolaux, Ophelie Not, Frederic Wallet, Frederic Daussin, Eric Boulanger, Arthur Durand, Marie Frimat, Alina Ghinet, Michael Howsam, William Laine, Philippe Marchetti, Jerome Kluza, Estelle Chatelain, Jimmy Vandel, Nicolas Barois, Valerie Montel, Bruno Bastide, Sebastien Preau, Steve Lancel   +27 more
doaj   +1 more source

Les déterminants de la conversion a l’agriculture biologique : une revue de la littérature économique [PDF]

, 2010
On se propose dans ce document de passer en revue les travaux, principalement en économie, visant à identifier les déterminants des conversions des exploitations à l’agriculture biologique.
Géniaux, Ghislain, Latruffe, Laure, Lepoutre, Jérôme, Mzoughi , Naoufel, Napoléone, Claude, Nauges, Céline, Sainte-Beuve, Jasmin, Sautereau, Natacha   +7 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Détermination automatique de la taille du pas de temps pour les schémas implicites en dynamique non linéaireAutomatic time-stepping algorithms for implicit schemes in non-linear dynamics [PDF]

Mécanique & Industries, 2002
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Why Firms Outsource Their Human Resources Activities: An Empirical Analysis [PDF]

In this paper, we develop and estimate an explanatory model of Human Resources Outsourcing. Six HR activities are analyzed: Payroll, Benefits, Recruiting, Training, Labor Relations, and Human Resources Information Systems. The determinants of outsourcing
Michel Patry, Michel Tremblay, Michelle Lacombe, Paul Lanoie   +3 more
core  

Les mesures du développement des cabinets d'audit internationaux : vers un élargissement du champ des mesures par le concept de légitimité [PDF]

, 2008
International audienceNotre article s'intéresse aux mesures du développement des cabinets d'audit internationaux. Ce phénomène est appréhendé à travers deux concepts distincts, à savoir le concept de « notoriété » et de « légitimité ».
Saidi Sellami, Sana
core   +2 more sources