Results 131 to 140 of about 83,781 (288)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Le vol en interne : les vols commis par les salariés sur leur lieu de travail
, 2007 International audienceCe travail fait le point sur la littérature en sciences sociales sur le vol en interne (les vols commis par les salariés sur leur lieu de travail).
Bonnet, François
core +2 more sources
La dynamique des intentions [PDF]
, 2002 Dans cet article, je soutiens que pour résoudre les principales difficultés rencontrées par les versions classiques de la théorie causale de l'action il est nécessaire non seulement faire appel à des intentions considérées comme des états mentaux ...
Pacherie, Elisabeth
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Analyse de la production sur la question des femmes dans les centres universitaires de criminologie au Canada de 1964 à 1989 [PDF]
, 1990 En 1990, la criminologie universitaire au Canada avait 25 ans. On comptait sept centres universitaires d’enseignement ou de recherche en criminologie au pays et ceux-ci regroupaient 125 professeurs/chercheurs.
Bertrand, Marie-Andrée +5 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Workplace Deviance Among Hotel Employees : An Exploratory Survey
Malaysian Management Journal, 2003 This exploratory study examined workplace deviance among hotel employees in Langkawi, Malaysia. Specifically, it attempted to provide empirical answers to two main research questions: (1) what are the types of workplace deviance employees exhibit at the ...
Faridahwati Mohd. Shamsudin
doaj
Un retardement de l'entrée dans la toxicomanie [PDF]
A partir d'un échantillon important d'usagers de drogues injectables interviewés dans cinq villes de France, nous avons délimité quatre générations en fonction de la date de la pre mière injection.
Lagrange, Hugues, Mogoutov, Andrei
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source