Results 81 to 90 of about 83,781 (288)

Des cheminements vers un style de vie déviant : adolescents des Centres jeunesse et des centres pour toxicomanes [PDF]

, 1998
Menée dans une perspective phénoménologique qui accorde une place de premier plan à l’interprétation que fait l’acteur social des situations et des événements qui le touchent, cette étude vise à recueillir la lecture que font les jeunes de leur ...
Brochu, Serge, Brunelle, Natacha, Cousineau, Marie-Marthe   +2 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Des juridictions d’exception pour « protéger » et « redresser » la jeunesse ? Les tribunaux pour mineurs sous la dictature franquiste (1939-1975) [PDF]

, 2011
International audienceIn 1918, in the same period as other Western countries, Spain set up juvenile courts which favored rehabilitation over punishment and aimed at isolating minors from adults and protecting them.
Nuq, Amélie
core   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Abusive Supervision and Workplace Deviance: The Moderating Role of Power Distance [PDF]

Pakistan Journal of Commerce and Social Sciences, 2019
The aim of this paper is to examine the association of abusive supervision with workplace deviance, for instance supervisory directed deviance, non-supervisory directed deviance, and emotional exhaustion.
Um-e-Laila , Salman Iqbal , Mamoona Rasheed   +2 more
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The Positive Relationships Between Paranoia, Perceptions of Workplace Bullying, and Intentions of Workplace Deviance in United Kingdom and French Teachers: Cross-Cultural Aspects

Frontiers in Psychiatry, 2020
Cognitive models of psychopathology were applied to inform the relationships between paranoid cognitions, perceptions of workplace bullying, and intentions of workplace deviance in UK and French teachers. Sixty-six UK teachers and 50 French teachers were
Bárbara Cristina Da Silva Lopes, Bárbara Cristina Da Silva Lopes, Catherine Bortolon, Válerie Macioce, Válerie Macioce, Stéphane Raffard, Stéphane Raffard   +6 more
doaj   +1 more source

Assister les familles de Québec : L’école de réforme et l’école d’industrie de l’Hospice Saint-Charles, 1870-1950 [PDF]

, 2008
Entre 1870 et 1950, plusieurs milliers de jeunes filles furent placées à l’école de réforme (1870-1921) et à l’école d’industrie (1884-1950) de l’Hospice Saint-Charles de Québec, dirigé par les Soeurs du Bon-Pasteur.
Gilbert, Dale
core   +1 more source