Results 121 to 130 of about 39,488,255 (246)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Letter from D. S. Smith, Seymour, Wisconsin, to A. J. Thompson, March 10, 1876

, 1876
A letter written by Mr. D. S. Smith of Seymour, Wisconsin, to Mr. A. J.
Smith, D. S.
core  

Precise measurement of the branching fractions for B-s(0) -> D-s(()*()+) D-s(()*()-) and first measurement of the D-s*(+) D-s*(-) polarization using e(+)e(-) collisions

, 2013
We have made a precise measurement of the absolute branching fractions of B-s(0) -> D-s(()*()+) D-s(()*()-) decays using 121.4 fb(-1) of data recorded by the Belle experiment running at the Upsilon(5S) resonance. The results are B(B-s(0) -> D-s(+) D-s(-))
Nakazawa, H., Horii, Y., Nitoh, O., Nakao, M., Röhrken, M., Hayashii, H., Li, Y., Ko, B. R., Sanuki, T., Kim, K. T., Smerkol, P., Gaur, V., Kiesling, C., Petric, M., Onuki, Y., Shapkin, M., Hou, W. -S., Kim, H. O., Kinoshita, K., Louvot, R., Lee, S.-H., Kawasaki, T., Ryu, S., Chistov, R., Chekelian, V., Sumiyoshi, T., Belous, K., Chilikin, K., Sokolov, A., Kim, Y. J., Sato, Y., Iwashita, T., Uchida, M., Itoh, R., Unno, Y., Natkaniec, Z., Iwabuchi, M., Li, J., Miyata, H., Liu, C., Yamaoka, J., Zhang, Z. P., Bozek, A., Ohshima, T., Uehara, S., Zhulanov, V., Kodys, P., Dalseno, J., Krizan, P., Schneider, O., Hara, T., Kim, M. J., Schwanda, C., Shwartz, B., Lee, S. -H., Staric, M., Aushev, T., Nishida, S., Park, H. K., Wang, M.-Z., Hou, W.-S., Koblitz, S., Julius, T., Shibata, T. -A., Krokovny, P., Watanabe, Y., ���������, Eidelman, S., Muramatsu, N., Stanic, S., Okuno, S., Asner, D. M., Iwasaki, Y., Bhuyan, B., Pestotnik, R., Shibata, T.-A., Nishimura, K., Park, H., Sohn, Y. -S., Roehrken, M., Haba, J., Kwon, Y.-J., Santel, D., Cho, I. -S., Trabelsi, K., Bakich, A. M., Sakai, Y., Pakhlova, G., Senyo, K., Kumita, T., Moll, A., Chen, A., Hsiung, Y. B., Mohapatra, D., Tatishvili, G., Hyun, H. J., Cho, I.-S., Cho, K., Mizuk, R., Kouzes, R. T., Feindt, M., Santelj, L., Chen, P., Drutskoy, A., Korpar, S., Choi, Y., Hoshi, Y., Olsen, S. L., Vahsen, S. E., Pedlar, T. K., Iijima, T., Won, E., Cheon, B. G., Park, C. W., Esen, S., Liventsev, D., Ng, C., Sevior, M. E., Wang, P., Solovieva, E., Danilov, M., Kwon, Y. -J., Williams, K. M., Vanhoefer, P., Shiu, J. -G., Ishikawa, A., Mconie, S., Uno, S., Libby, J., Schwartz, A. J., Shiu, J.-G., Dolezal, Z., Yamashita, Y., Tsuboyama, T., Uglov, T., Bracko, M., Wang, C. H., Kuhr, T., Sibidanov, A., Sohn, Y.-S., Liu, Y., Aihara, H., Piilonen, L. E., Wang, M. -Z., Simon, F., Varner, G., Zhilich, V., Kang, J. H., Browder, T. E., Teramoto, Y.   +149 more
core   +1 more source

Research of Intelligent Prediction System of Fault Signs of Asynchronous Motor Based on Information Fusio

Gong-kuang zidonghua, 2010
The fault mechanism of asynchronous motor is complex,single information can only reflect some fault aspects of asynchronous motor system,the conclusion coming from single information has uncertainty.Especially when asynchronous motor is in early ...
TIAN Mu-qin, LIU Zhi-heng, HAI Zhen-hong
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A trust evaluation algorithm for wireless sensor networks based on node behaviors and D-S evidence theory. [PDF]

Sensors (Basel), 2011
Feng R, Xu X, Zhou X, Wan J.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Wetting: Theory and Experiment

, 2005
Comitato organizzatore: Amy Novick-Cohen, Alexander Nepomnyashchy, Leonid Pismen. Comitato Scientifico: M. Ben Amar, S. Davis, L. Giacomelli, G. Gruen, J. King, D. Mukamel, A. Nepomnyashchy, A. Novick-Cohen, L. Pismen, Y. Pomeau, D. Quere.
A. Novick Cohen, G. Gruen, J. King, M. Ben Amar, L. Pismen, A. Nepomnyashchy, S. Davis, GIACOMELLI, Lorenzo, D. Mukamel, D. Quere, Y. Pomeau   +10 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source