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Manufacturing Supply Chains and Imports in the ADHD Drug Shortage.
JAMA Health ForumCurrie J, Malinovskaya A.
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Protection against d-amphetamine toxicity
The American Journal of Emergency Medicine, 1990The efficacy of diazepam, haloperidol, propranolol, and yohimbine in antagonizing the toxic manifestations of d-amphetamine were studied in rats. In the control group of animals given 75 mg/kg intraperitoneal (ip) d-amphetamine, 95% developed seizures, and 100% died in mean times of 12.6 +/- 1.0 and 50.1 +/- 5.9 minutes, respectively.
R W, Derlet, T E, Albertson, P, Rice
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Effect of D-amphetamine on menstruation
American Journal of Obstetrics and Gynecology, 1969IN .4 RETROSPECTIVE paper, “A Gynecologiic Study of Addicts,“l 5 of 7 patients abusing large doses of amphetamine were reported to have increased flow, duration, and cramping of the menses. In addition, dataIsuggested that adrenergic drugs, such as amphetamines, might lead ‘to increased gonadotropin output.
S S, Stoffer +3 more
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D-Amphetamine in obsessive-compulsive disorder
Psychopharmacology, 1983In a double-blind crossover study, single doses of d-amphetamine and placebo were administered to 12 patients with severe chronic obsessive-compulsive disorder (OCD). Improvement of obsessional symptoms was significant on clinical ratings and was correlated with improved performance on an attention task.
T R, Insel +3 more
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Vasoconstriction and D-Amphetamine-Induced Hypothermia
International Journal of Neuroscience, 1981The hypothermic effect of d-amphetamine was investigated in rats in which vasoconstriction or vasodilation was induced by pharmacological agents: aramine as vasoconstrictor and neprasol as vasodilator. The d-amphetamine-induced hypothermia was enhanced by both drugs among rats kept at 4 degrees C, and both drugs were unable to modify the d-amphetamine ...
S, Yehuda, R L, Carasso, Y, Ben-Uriah
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Task-specific tolerance to d-amphetamine
Neuropharmacology, 1984Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for ...
M W, Emmett-Oglesby +3 more
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d-amphetamine binding to brain lipid
Neurochemical Research, 1978The interaction of d-amphetamine with several brain tissue components has been investigated. A brain lipid extract and a number of individual phospholipids were found to bind d-amphetamine when measured by means of a hexane-buffer partition coefficient technique.
M A, Goldberg, T, Todoroff
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Female rats that rapidly acquire a d-amphetamine discrimination generalize more to d-amphetamine
Pharmacology Biochemistry and Behavior, 1996Female Long-Evans rats were trained to discriminate d-amphetamine (0.8 mg/kg) vs. saline in a food-reinforced two-lever operant task. Fifteen rats (fast group) acquired the discrimination rapidly, achieving criterion (eight correct choices within ten sessions) during the first 10 sessions (mean sessions to criterion = 10.0).
A, Tomie, E M, Mosakowski
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Tolerance to d-amphetamine: Behavioral specificity
Life Sciences, 1976Abstract In a Y-maze exploratory task mice tend to enter that compartment which was least recently visited (spontaneous alternation). Low doses of d-amphetamine (1.0 mg/kg) reduce alternation to chance levels, while high doses (10.0 mg/kg) result in animals successively visiting only two compartments of the Y-maze (perseveration).
L, Kokkinidis +3 more
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