Results 221 to 230 of about 42,834 (276)
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Journal of the Neurological Sciences, 1975
Guinea pigs exhibit an increased sensitivity to both d-amphetamine- and apomorphine-induced stereotyped behavior following chronic pretreatment with d-amphetamine. This chronic agonist or "innervation" supersensitivity is believed to be a reflection of an increased sensitivity of dopamine receptor sites within the corpus striatum to dopaminergic ...
H L, Klawans +3 more
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Guinea pigs exhibit an increased sensitivity to both d-amphetamine- and apomorphine-induced stereotyped behavior following chronic pretreatment with d-amphetamine. This chronic agonist or "innervation" supersensitivity is believed to be a reflection of an increased sensitivity of dopamine receptor sites within the corpus striatum to dopaminergic ...
H L, Klawans +3 more
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Ganglionic blockade by d-amphetamine
European Journal of Pharmacology, 1983The actions of d-amphetamine on ganglionic transmission in the isolated stellate ganglion of the hamster were observed. Blockade of the compound action potential by d-amphetamine had a slow onset with an onset half-time of 2-5 min. The concentration-blockade relationship for d-amphetamine was not shifted by phentolamine (10(-5) M) or propranolol (10(-6)
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Self-administration of d-amphetamine by rats
Psychopharmacologia, 1968Self-administration of d-amphetamine by rats was characterized by periods of drug intake and abstinence. Frequency of responding for drug injection was found to vary inversely as a function of drug dose per infusion (magnitude of reinforcement), and directly as a function of number of responses required per infusion (fixed-ratio reinforcement schedule).
R, Pickens, W C, Harris
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Potentiation of morphine analgesia by d-amphetamine
Psychopharmacology, 1986Rats were trained to escape from aversive electrical brain stimulation delivered to the mesencephalic reticular formation (MRF). The threshold for this escape behavior was determined by a modification of the classic psychophysical method of limits. Escape thresholds were determined after the administration of morphine alone, d-amphetamine alone, and ...
S, Sasson, E M, Unterwald, C, Kornetsky
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Drug and Alcohol Dependence, 2004
Flexibility of drug taking is characteristic for "controlled" drug consumption whereas addiction is reflected by inflexibility and persistent high risk to relapse. Male Wistar rats (N = 12) that were given a continuous free choice between water and D-amphetamine solutions for 16 weeks, revealed a moderate and flexible pattern of D-amphetamine intake ...
Gabriel, Galli, Jochen, Wolffgramm
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Flexibility of drug taking is characteristic for "controlled" drug consumption whereas addiction is reflected by inflexibility and persistent high risk to relapse. Male Wistar rats (N = 12) that were given a continuous free choice between water and D-amphetamine solutions for 16 weeks, revealed a moderate and flexible pattern of D-amphetamine intake ...
Gabriel, Galli, Jochen, Wolffgramm
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Sociopharmacology of d-amphetamine in Macaca arctoides
Pharmacology Biochemistry and Behavior, 1980This study was designed to assess the effects of acute d-amphetamine pretreatment on the social behavior of a heterosexual group of adult M. arctoides. The dominance status had been previously determined by use of daily group food competition tests. Prior to some sessions amphetamine was administered to a single group member; whereas on other occasions
A, Bellarosa, J A, Bedford, M C, Wilson
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Effects of d-amphetamine on arousal
Neuroscience & Biobehavioral Reviews, 1992This article is a review of studies conducted on the effects of amphetamine on behavior in animals by the late Walter Isaac and his associates. The principle findings and hypotheses developed over the 20 or more years of research are outlined and discussed.
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Repeated d -amphetamine enhances stimulated mesoamygdaloid dopamine transmission
Psychopharmacology, 1997The mesoaccumbens dopamine pathway exhibits an enhanced dopaminergic response to a challenge injection of d-amphetamine or cocaine after repeated intermittent exposure to that drug. Much research has focused on the potential role of this sensitised response in the enhanced propensity of drug-associated stimuli to elicit relapse.
Harmer, C. J +3 more
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Interaction between ?9-Tetrahydrocannabinol and d-amphetamine
Psychopharmacology, 1977d-Amphetamine increases the motor activity at a dose range of 0.5-4 mg/kg. delta(9)-Tetrahydrocannabinol (THC) diminishes this effect dose-dependently. Also, the hyperthermia caused by 5 mg/kg d-amphetamine is antagonized by THC, whereas the d-amphetamine induced stereotype movements (above 4 mg/kg) are prolonged by the cannabinoid.
C, Hattendorf +3 more
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Pharmacology Biochemistry and Behavior, 2013
Modafinil is a novel wake-promoting drug with FDA approval for the treatment of sleep-related disorders that has recently been investigated as a potential agonist replacement therapy for psychostimulant dependence. Previous research in animals and humans indicates modafinil has a lower abuse liability than traditional psychostimulants, although few ...
Amanda J, Quisenberry +2 more
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Modafinil is a novel wake-promoting drug with FDA approval for the treatment of sleep-related disorders that has recently been investigated as a potential agonist replacement therapy for psychostimulant dependence. Previous research in animals and humans indicates modafinil has a lower abuse liability than traditional psychostimulants, although few ...
Amanda J, Quisenberry +2 more
openaire +2 more sources