Results 91 to 100 of about 1,724,790 (267)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Estimation Of Probiotic And Vitamine D Efficiency In Prophylactics Of Infectious Diseases In Premature Infants

Journal of Education, Health and Sport, 2017
Aryaev N. L., Shevchenko I. M., Moskalenko T. Ya., Mezevgi J. M. El., Shevchenko N. V. Estimation of probiotic and vitamine D efficiency in prophylactics of infectious diseases in premature infants. Journal of Education, Health and Sport. 2017;7(6):571-582. eISSN 2391-8306.
N. L. Aryaev, I. M. Shevchenko, T. Ya. Moskalenko, J. M. El Mezevgi, N. V. Shevchenko   +4 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Robust D-Optimal Mixture Designs Under Manufacturing Tolerances via Multi-Objective NSGA-II

Mathematics
This study proposes a multi-objective optimization framework for generating statistically efficient and operationally robust designs in constrained mixture experiments with irregular experimental regions. In industrial settings, manufacturing variability
Wanida Limmun, Boonorm Chomtee, John J. Borkowski   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Thermal and hydrodynamic characteristics of Therminol VP-1 oil flow across perforated conical hollow turbulence promoter in Scheffler dish receiver tube

Scientific Reports
This study examines the thermal and hydrodynamic characteristics of Therminol VP-1 oil flow through perforated conical hollow-type turbulence promoters installed in a solar Scheffler dish collector receiver tube, utilizing computational fluid dynamics ...
Anil Kumar, Ram Kunwer, Nikhil Kanojia, Tabish Alam, Md Irfanul Haque Siddiqui, Dan Dobrota, Intesaaf Ashraf   +6 more
doaj   +1 more source

Impact of Digital Guidance on Accuracy, Reliability, and Time Efficiency of Wound Measurements

IEEE Open Journal of Instrumentation and Measurement
Wound size measurement is essential for clinical assessment, as it can indicate the patient’s healing progress and influence clinical decisions. Healthcare providers traditionally use physical wound measurement methods, such as rulers and digital ...
Dahlia Musa, Frank Guido-Sanz, Mindi Anderson, Desiree A. Diaz, Salam Daher   +4 more
doaj   +1 more source