Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 1997 A box constrained variational inequality problem can be reformulated as an unconstrained minimization problem through the D-gap function. A hybrid Netwon-type method is proposed for minimizing the D-gap function.
Fukushima, Masao +2 more
core
Electronic structure reconstruction and low-energy optical response in La/Co-codoped BaTiO<sub>3</sub>: a first-principles study. [PDF]
RSC AdvQiu J, Li C, Zhang C, Luo X.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Using additional information in estimating output gap in Peru: a multivariate unobserved component approach [PDF]
One of the key inputs for inflation targeting regime is the right identification of inflationary or disinflationary pressures. These pressures are usually approximated by the output gap.
Gonzalo Llosa/Shirley Miller
core
Gap junction innexin asymmetry in C. elegans suggests a diode blocking mechanism to prevent antidromic backpropagation from motor neurons to command interneurons. [PDF]
MicroPubl BiolWhite J.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Transatlantic Productivity Gap: Is R&D the Main Culprit? [PDF]
The literature has pointed to different causes to explain the productivity gap between Europe and United States in the last decades. This paper tests the hypothesis that the lower European productivity performance in comparison with the US can be ...
Ortega-Argilés, Raquel +2 more
core
Nematic and chiral superconductivity emerging within the loop-current phase in kagome metals. [PDF]
Nat CommunTazai R, Yamakawa Y, Kontani H.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source