Identification of the genes that contribute to lactate utilization in Helicobacter pylori. [PDF]
PLoS ONE, 2014 Helicobacter pylori are Gram-negative, spiral-shaped microaerophilic bacteria etiologically related to gastric cancer. Lactate utilization has been implicated although no corresponding genes have been identified in the H. pylori genome.
Shun Iwatani +5 more
doaj +1 more source
, 2022 Mycobacterium tuberculosis (Mtb) produces an unconventional flavohemoglobin (MtbFHb) that carries a FAD-binding site similar to D-lactate dehydrogenases (D-LDH) and oxidizes D-lactate into pyruvate.
Naveen Thakur (12068144) +6 more
core +1 more source
Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]
, 2011 Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Vazquez, Alexei +8 more
core +2 more sources
D-Lactate Production and Excretion in Diarrheic Calves [PDF]
Journal of Veterinary Internal Medicine, 2004 Abstract The origin of D-lactate, the most important acid contributing to metabolic acidosis in the diarrheic calf, is unknown. We hypothesized that because D-lactate is produced only by microbes, gastrointestinal fermentation is the source. The objective of this study was to determine whether D-lactate production occurs in the rumen,
Julia B, Ewaschuk +4 more
openaire +2 more sources
Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]
, 1993 Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Schneider, Uwe +7 more
core +1 more source
Journal of Health, Population and Nutrition, 2023 Background The elevated circulating toxins secondary to the impairment of intestinal barrier integrity commonly elicit a chronic inflammatory response and finally contribute to multiple diseases.
Ye Tian +13 more
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The effects of 5 days β-alanine supplementation on the velocity and the percentage o2max at the lactate threshold [PDF]
, 2010 Purpose: To assess the effect of 5 days β-alanine supplementation on the velocity and the percentage of O2max ¬¬ (%O2max) at the lactate threshold (Tlac) during treadmill running.
Johnson, Matthew
core +2 more sources
D-lactic Acidosis: Successful Suppression of D-lactate-Producing Lactobacillus by Probiotics. [PDF]
, 2018 Intestinal microbiota composition in children with short bowel syndrome (SBS) is an important factor influencing the clinical outcome. An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy,
Macpherson, Andrew +3 more
core +1 more source
Microbiota-derived D-lactate alters macrophage inflammation [PDF]
, 2022 Obesity-induced inflammation is a factor involved in the risk and progression of type 2 diabetes and non-alcoholic fatty liver disease. These diseases are associated with changes in gut microbiota composition and bacterial metabolites.
Singh, Anita
core +1 more source
Oxidation of D-lactate and L-lactate by Neisseria meningitidis: purification and cloning of meningococcal D-lactate dehydrogenase [PDF]
Journal of Bacteriology, 1993 Neisseria meningitidis was found to contain at least two lactate-oxidizing enzymes. One of these was purified 460-fold from spheroplast membranes and found to be specific primarily for D-lactate, with low-affinity activity for L-lactate. The gene for this enzyme (dld) was cloned, and a dld mutant was constructed by insertional inactivation of the gene.
A L, Erwin, E C, Gotschlich
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