Results 11 to 20 of about 13,889,634 (275)

Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate [PDF]

BMC Microbiology, 2010
Background Corynebacterium glutamicum is able to grow with lactate as sole or combined carbon and energy source. Quinone-dependent L-lactate dehydrogenase LldD is known to be essential for utilization of L-lactate by C. glutamicum.
Oikawa Tadao, Matsui Daisuke, Stansen K Corinna, Youn Jung-Won, Kato Osamu, Wendisch Volker F   +5 more
doaj   +6 more sources

Identification of human D lactate dehydrogenase deficiency [PDF]

Nature Communications, 2019
D-lactic acidosis typically occurs in the context of short bowel syndrome; excess D-lactate is produced by intestinal bacteria. Here, the authors identify two point mutations in the human lactate dehydrogenase D (LDHD) gene that cause enzymatic loss of ...
Glen R. Monroe, Albertien M. van Eerde, Federico Tessadori, Karen J. Duran, Sanne M. C. Savelberg, Johanna C. van Alfen, Paulien A. Terhal, Saskia N. van der Crabben, Klaske D. Lichtenbelt, Sabine A. Fuchs, Johan Gerrits, Markus J. van Roosmalen, Koen L. van Gassen, Mirjam van Aalderen, Bart G. Koot, Marlies Oostendorp, Marinus Duran, Gepke Visser, Tom J. de Koning, Francesco Calì, Paolo Bosco, Karin Geleijns, Monique G. M. de Sain-van der Velden, Nine V. Knoers, Jeroen Bakkers, Nanda M. Verhoeven-Duif, Gijs van Haaften, Judith J. Jans   +27 more
doaj   +7 more sources

The Serum Citrulline and D-Lactate are Associated with Gastrointestinal Dysfunction and Failure in Critically Ill Patients [PDF]

International Journal of General Medicine, 2021
Jin Teng,1 Lu Xiang,2 Huaicong Long,2 Caiping Gao,3 Lei Lei,3 Yinghui Zhang3 1Department of Cadre Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu City, Sichuan Province, 610072, People’s Republic of China ...
Teng J, Xiang L, Long H, Gao C, Lei L, Zhang Y   +5 more
doaj   +2 more sources

d-Lactate transport and metabolism in rat liver mitochondria [PDF]

Biochemical Journal, 2002
In the present study we investigated whether isolated rat liver mitochondria can take up and metabolize d-lactate. We found the following: (1) externally added d-lactate causes oxygen uptake by mitochondria [P/O ratio (the ratio of mol of ATP synthesized to mol of oxygen atoms reduced to water during oxidative phosphorylation) = 2] and membrane ...
de Bari L, Atlante A, Guaragnella N, Principato G, Passarella S   +4 more
core   +6 more sources

Glyoxalase 2 Drives D-Lactate Oncometabolite Signaling to Promote Prostate Cancer Aggressiveness via FAK/Src Activation [PDF]

Antioxidants
Glyoxalase 2 (Glo2) is a key enzyme of the glyoxalase system that catalyzes the conversion of S-lactoylglutathione (LSG) into glutathione (GSH) and D-lactate.
Dominga Manfredelli, Camilla Torcoli, Veronica Ceccarelli, Tatiana Armeni, Guido Bellezza, Vincenzo N. Talesa, Angelo Sidoni, Cinzia Antognelli   +7 more
doaj   +2 more sources

New Insights Into the Function of Flavohemoglobin in Mycobacterium tuberculosis: Role as a NADPH-Dependent Disulfide Reductase and D-Lactate-Dependent Mycothione Reductase [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Mycobacterium tuberculosis (Mtb) produces an unconventional flavohemoglobin (MtbFHb) that carries a FAD-binding site similar to D-lactate dehydrogenases (D-LDH) and oxidizes D-lactate into pyruvate.
Naveen Thakur, Amar Nath Sharma, Mangesh Dattu Hade, Ajay Chhaya, Ashwani Kumar, Ravinder Singh Jolly, Kanak L. Dikshit, Kanak L. Dikshit   +7 more
doaj   +2 more sources

Serum D-lactate, a novel serological biomarker, is promising for the diagnosis of periprosthetic joint infection [PDF]

BMC Musculoskeletal Disorders, 2022
Background Although many markers are used for diagnosis of periprosthetic joint infection (PJI), serological screening and diagnosis for PJI are still challenging.
Yanyang Chen, Huhu Wang, Xiyao Chen, Hairong Ma, Jingjie Zheng, Li Cao   +5 more
doaj   +2 more sources

Stereospecific lactylation in bacteriology: L/D-lactate partitioning shapes host metabolic-disease axis [PDF]

Frontiers in Microbiology
Two stereoisomers of lactate, L- and D-lactate, serve as critical conduits for bidirectional communication in host-bacteria interactions and the development of diseases.
Sirui Wang, Sirui Wang, Leiliang Zhang, Leiliang Zhang   +3 more
doaj   +2 more sources

L- and D-Lactate: unveiling their hidden functions in disease and health [PDF]

Cell Communication and Signaling
Lactate, once considered a mere byproduct of anaerobic metabolism, is now recognized as a critical signaling molecule with diverse roles in physiology and pathology. There are two stereoisomers of lactate: L- and D-lactate. Recent studies have shown that
Jianting Li, Peng Ma, Zhizhen Liu, Jun Xie   +3 more
doaj   +2 more sources

Transport and metabolism of d-lactate in Jerusalem artichoke mitochondria [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005
We report here initial studies on D-lactate metabolism in Jerusalem artichoke. It was found that: 1) D-lactate can be synthesized by Jerusalem artichoke by virtue of the presence of glyoxalase II, the activity of which was measured photometrically in both isolated Jerusalem artichoke mitochondria and cytosolic fraction after the addition of S-D-lactoyl-
Atlante A, de Bari L, Valenti D, Pizzuto R, Paventi G, Passarella S   +5 more
openaire   +4 more sources