D-Lactate: Implications for Gastrointestinal Diseases [PDF]
Children, 2023 D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take ...
Barblin Remund +2 more
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The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle [PDF]
Frontiers in Veterinary ScienceD-lactic acidosis is associated with fermentative disturbances and is often marked by elevated levels of D-lactic acid in the blood, ruminal fluid, and synovial fluid in cattle.
Rafael Agustín Burgos +9 more
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Serum D-Lactate Concentrations in Dogs with Inflammatory Bowel Disease [PDF]
AnimalsThe D-enantiomer of lactic acid (D-lactate) is normally produced from bacterial fermentation in the gastrointestinal tract in mammals. In humans, increased D-lactate concentrations are related to gastrointestinal disease, including short bowel syndrome ...
Giulia Maggi +9 more
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Serum D‐lactate concentrations in dogs with parvoviral enteritis [PDF]
Journal of Veterinary Internal Medicine, 2020 Background Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D‐lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid‐base status in these dogs ...
Emilee C. Venn +5 more
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D-lactate is a promising biomarker for the diagnosis of periprosthetic joint infection [PDF]
Frontiers in Surgery, 2022 IntroductionReliable biomarkers for the diagnosis of periprosthetic joint infection (PJI) are of paramount clinical value. To date, synovial fluid leukocyte count is the standard surrogate parameter indicating PJI.
M. Fuchs +6 more
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Early detection of plasma d-lactate: Toward a new highly-specific biomarker of bacteraemia? [PDF]
Heliyon, 2023 Background: Bloodstream infections are a leading cause of mortality. Their detection relies on blood cultures (BCs) but time to positivity is often between tens of hours and days.
Charles R. Lefèvre +10 more
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Characterization of a membrane-bound PQQ-dependent d-lactate dehydrogenase in Gluconobacter japonicus [PDF]
Applied Microbiology and BiotechnologyMembrane-bound pyrroloquinoline quinone (PQQ)–dependent quinoproteins are key components of the periplasmic oxidative metabolism of acetic acid bacteria, yet several predicted enzymes remain experimentally uncharacterized.
Naoya Kataoka +5 more
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Biosensor-assisted CRISPRi high-throughput screening to identify genetic targets in Zymomonas mobilis for high d-lactate production [PDF]
Synthetic and Systems BiotechnologyLactate is an important monomer for the synthesis of poly-lactate (PLA), which is a substitute for the petrochemical plastics. To achieve the goal of high lactate titer, rate, and yield for commercial production, efficient lactate production pathway is ...
Qiqun Peng +3 more
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Human D‐Lactate Dehydrogenase Deficiency: A Case Report in a Young Boy [PDF]
JIMD ReportsD‐lactate is an isomeric form of lactate, which is almost undetectable in the circulation in individuals with normal lactate metabolism. Patients diagnosed with the disease human D‐lactate dehydrogenase deficiency present with elevated plasma D‐lactate ...
T. B. Sloth +5 more
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Improving autotrophic D-lactate production by heterologous expression of a pyruvate formate lyase in an LDHD-expressing Acetobacterium woodii strain [PDF]
Applied Microbiology and BiotechnologyThe anaerobic acetogen Acetobacterium woodii is a promising candidate producing chemicals while converting the greenhouse gas CO2. In this study, A.
Kira S. Baur +3 more
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