Results 71 to 80 of about 3,379,244 (276)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Antioxidants, 2017 The optimum conditions for the antioxidant extraction from maqui berry were determined using a response surface methodology. A three level D-optimal design was used to investigate the effects of three independent variables namely, solvent type (methanol,
Issis Quispe-Fuentes +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Load Reconstruction Technique Using D-Optimal Design and Markov Parameters
Shock and Vibration, 2015 This paper develops a technique for identifying dynamic loads acting on a structure based on impulse response of the structure, also referred to as the system Markov parameters, and structure response measured at optimally placed sensors on the structure.
Deepak K. Gupta, Anoop K. Dhingra
doaj +1 more source
An extended Generalised Variance, with Applications [PDF]
, 2015 We consider a measure $\psi$ k of dispersion which extends the notion of Wilk's generalised variance, or entropy, for a d-dimensional distribution, and is based on the mean squared volume of simplices of dimension k $\le$ d formed by k + 1 independent ...
Pronzato, Luc +2 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Extensions of D-optimal Minimal Designs for Symmetric Mixture Models. [PDF]
, 2017 The purpose of mixture experiments is to explore the optimum blends of mixture components, which will provide desirable response characteristics in finished products.
Chervoneva, Inna +2 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A Regular D‑optimal Weighing Design with Negative Correlations of Errors
Acta Universitatis Lodziensis. Folia Oeconomica, 2019 The issues concerning optimal estimation of unknown parameters in the model of chemical balance weighing designs with negative correlated errors are considered. The necessary and sufficient conditions determining the regular D‑optimal design and some new
Małgorzata Graczyk, Bronisław Ceranka
doaj +1 more source