Results 71 to 80 of about 3,230,091 (259)

Design of a new prebiotic beef snack formulation by D-optimal mixture design

Journal of Agriculture and Food Research
This study optimized a prebiotic beef snack formulation using inulin, wheat flour, and corn flour at a 12 % ratio via the D-optimal mixture design. Samples were analyzed for physicochemical and sensory properties.
Hassan Dadkhah, Mansoureh Taghizadeh, Fatemeh Barzegar, Nader Karimian Khosroshahi, Kooshan Nayebzadeh, Abdorreza Mohammadi, Hedayat Hosseini, Soheil Eskandari, Amin Mousavi Khaneghah   +8 more
doaj   +1 more source

Optimization of the chemoenzymatic mono-epoxidation of linoleic acid using D-optimal design

Journal of Saudi Chemical Society, 2011
Mono-epoxied linoleic acid 9(12)-10(13)-monoepoxy 12(9)-octadecanoic acid (MEOA) was synthesized and optimized by immobilized Candida antarctica lipase (Novozym 435®) using D-optimal design. For optimizing the reaction, response surface methodology (RSM)
B. Abdullah, N. Salih, J. Salimon
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Optimization, physical-chemical evaluation and healing activity of chitosan ointment [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2019
Context: Chitosan has received attention as a functional, sustainably renewable, nontoxic and biodegradable biopolymer for pharmaceutical applications such as healing agent.
Dania Pérez, Nilia de la Paz, Mirna Fernández, Niurys Mantilla, Mariela Peña, Addis Menéndez   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Saponification of Jatropha curcas Seed Oil: Optimization by D-Optimal Design

International Journal of Chemical Engineering, 2012
In this study, the effects of ethanolic KOH concentration, reaction temperature, and reaction time to free fatty acid (FFA) percentage were investigated.
Jumat Salimon, Bashar Mudhaffar Abdullah, Nadia Salih   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation. [PDF]

Int J Nanomedicine, 2023
Hu Q, Fu XL, Dong YY, Ma J, Hua J, Li JT, Liu KX, Yang J, Yu CX.   +8 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source