Results 71 to 80 of about 24,770,333 (307)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
D-optimal population designs in linear mixed effects models for multiple longitudinal data
Statistical Theory and Related Fields, 2021 The main purpose of this paper is to investigate D-optimal population designs in multi-response linear mixed models for longitudinal data. Observations of each response variable within subjects are assumed to have a first-order autoregressive structure ...
Hongyan Jiang, Rongxian Yue
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
D-optimal Saturated Designs: A Simulation Study [PDF]
, 2014 8 pages.
Fontana, Roberto +2 more
openaire +5 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Load Reconstruction Technique Using D-Optimal Design and Markov Parameters
Shock and Vibration, 2015 This paper develops a technique for identifying dynamic loads acting on a structure based on impulse response of the structure, also referred to as the system Markov parameters, and structure response measured at optimally placed sensors on the structure.
Deepak K. Gupta, Anoop K. Dhingra
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Drug Delivery, 2017 Agomelatine is a new antidepressant having very low oral drug bioavailability less than 5% due to being liable to extensive hepatic 1st pass effect. This study aimed to deliver agomelatine by transdermal route through formulation and optimization of ...
Mayada Said +3 more
doaj +1 more source
A Regular D‑optimal Weighing Design with Negative Correlations of Errors
Acta Universitatis Lodziensis. Folia Oeconomica, 2019 The issues concerning optimal estimation of unknown parameters in the model of chemical balance weighing designs with negative correlated errors are considered. The necessary and sufficient conditions determining the regular D‑optimal design and some new
Małgorzata Graczyk, Bronisław Ceranka
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source