Results 101 to 110 of about 231,256 (313)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimal designs for rating-based conjoint experiments. [PDF]

The scope of conjoint experiments on which we focus embraces those experiments in which each of the respondents receives a different set of profiles to rate.
Goos, Peter, Vandebroek, Martina, Kessels, Roselinde   +2 more
core  

Combined algorithm to compute D-optimal designs

Journal of Computational and Applied Mathematics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Raúl Martín Martín, Irene García Camacha Gutiérrez   +1 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Maximin optimal designs for the compartmental model [PDF]

For the compartmental model we determine optimal designs, which are robust against misspecifications of the unknown model parameters. We propose a maximin approach based on D-efficiencies and provide designs that are optimal with respect to the ...
Dette, Holger, Pepelyshev, Andrey, Biedermann, Stefanie   +2 more
core  

Variance exchange process: overcoming the problem of singular information matrices in quadratic three−variable response designs

Journal of Innovative Applied Mathematics and Computational Sciences
Many a time, in a variance exchange process looking for D-optimal designs, the initial designs of all quadratic components of three-variable response polynomials produce non-invertible information matrices.
Okim Ikpan, Felix Nwobi
doaj   +1 more source

Piani D-ottimali non equivalenti di risoluzione V con N = 10, 12 osservazioni

Statistica, 2007
In the literature there are several contributions to the construction of resolution V D-optimal designs when N_=2 mod 16 (Chadjiconstantinidis, Cheng and Moyssiadis, 1989).
Luigi Salmaso
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bayesian designs for hierarchical linear models [PDF]

, 2012
Two Bayesian optimal design criteria for hierarchical linear models are discussed – the ?? criterion for the estimation of individual-level parameters ?, and the ?? criterion for the estimation of hyperparameters ?.
Allenby, Gregory, Qing Liu, Dean, Angela, Liu, Qing, Angela M. Dean, Greg M. Allenby   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source