Results 111 to 120 of about 16,379,393 (306)
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Combined algorithm to compute D-optimal designs
Journal of Computational and Applied Mathematics, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Raúl Martín Martín +1 more
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A geometric characterization of c-optimal designs for heteroscedastic regression [PDF]
We consider the common nonlinear regression model where the variance as well as the mean is a parametric function of the explanatory variables. The c-optimal design problem is investigated in the case when the parameters of both the mean and the variance
Dette, Holger, Holland-Letz, Tim
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exploiting correlation in the construction of D-optimal response surface designs. [PDF]
Cost considerations and difficulties in performing completely randomized experiments often dictate the necessity to run response surface experiments in a bi-randomization format.
Goos, Peter, Vandebroek, Martina
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Optimal designs for estimating the slope of a regression [PDF]
In the common linear regression model we consider the problem of designing experiments for estimating the slope of the expected response in a regression.
Dette, Holger, Melas, Viatcheslav B.
core
Robust D-Optimal Mixture Designs Under Manufacturing Tolerances via Multi-Objective NSGA-II
MathematicsThis study proposes a multi-objective optimization framework for generating statistically efficient and operationally robust designs in constrained mixture experiments with irregular experimental regions. In industrial settings, manufacturing variability
Wanida Limmun +2 more
doaj +1 more source