Results 131 to 140 of about 231,256 (313)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Semi-bayesian D-optimal designs and estimation procedures for mean and variance functions. [PDF]
Semi-Bayesian D-optimal designs for fitting mean and variance functions are derived for some prior distributions on the variance function parameters. The impact of the mean of the prior and of the uncertainty about this mean is analyzed.
Goos, Peter, Vandebroek, Martina
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Efficient experimental designs for sigmoidal growth models [PDF]
For the Weibull- and Richards-regression model robust designs are determined by maximizing a minimum of D- or D1-efficiencies, taken over a certain range of the non-linear parameters.
Dette, Holger, Pepelyshev, Andrey
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Журнал Белорусского государственного университета: Математика, информатика, 2020 Error in the article "Construction D-optimal designs of experiments for linear multiple regression with heteroscedastic observations"
Valery P. Kirlitsa
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Geometric construction of optimal designs for dose-responsemodels with two parameters [PDF]
In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a ...
Zhu, Wei +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Havacılık ve Uzay Teknolojileri Dergisi, 2007 The purpose of this study is to study the efficiency of several “design of experiments” (DOE) approaches used for the analysis and optimization of engineering designs.
Fatih Erdoğan
doaj
Statistical Theory and Related FieldsIn mixture experiments, the observed response is determined by the relative proportions of the components, consequently rendering the experimental region a simplex.
Jiawei Bao, Yu Tang
doaj +1 more source