Results 71 to 80 of about 16,379,393 (306)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
D-optimal Saturated Designs: A Simulation Study [PDF]
, 2014 8 pages.
Fontana, Roberto +2 more
openaire +5 more sources
Optimal designs for indirect regression [PDF]
, 2004 In many real life applications, it is impossible to observe the feature of interest directly. For example, scientists in Materials Science may be interested in detecting cracks inside objects, not visible from the outside. Similarly, non-invasive medical
Edmund Jones +58 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
D-optimal and highly D-efficient designs with non-negatively correlated observations [PDF]
, 2016 summary:In this paper we consider D-optimal and highly D-efficient chemical balance weighing designs. The errors are assumed to be equally non-negatively correlated and to have equal variances.
Katulska, Krystyna, Smaga, Łukasz
core +1 more source
Rancangan D-Optimal Model Gompertz dengan Maple
Media Statistika, 2017 Gompertz model is used in many areas including biological growth studies, animal and husbandry, chemistry, and agricultural. Locally D-optimal designs for Gompertz models with three parameters is investigated.
Tatik Widiharih, Budi Warsito
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Optimal cross-over designs for full interaction models [PDF]
, 2013 We consider repeated measurement designs when a residual or carry-over effect may be present in at most one later period. Since assuming an additive model may be unrealistic for some applications and leads to biased estimation of treatment effects, we ...
P. Druilhet +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Bayesian sequential D-D optimal model-robust designs. [PDF]
Alphabetic optimal design theory assumes that the model for which the optimal design is derived is usually known. However in real-life applications, this assumption may not be credible, as models are rarely known in advance.
Ruggoo, A, Vandebroek, Martina
core