Results 171 to 180 of about 10,339,939 (316)
Correction: SSNdesign-An R package for pseudo-Bayesian optimal and adaptive sampling designs on stream networks. [PDF]
PLoS OnePearse AR +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
An optimality-theoretic typology of case and grammatical voice systems
, 1993 In this paper we explore the consequences of the hypothesis that Universal Grammar contains formal counterparts of extremely simple constraints like these: agents surface as subjects; low-prominence arguments do not surface as subjects or objects; low ...
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Combining Optimality Theory and a Cognitive Architecture
, 2003 Optimality Theory (OT) has had a lot of attention from the linguistics research community but also still largely lacks cognitive grounding. We used the ACT-R cognitive architecture to gain greater insight into the cognitive grounding issues that OT needs
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Theoretical morphospace reveals mixed optimisation of the avian wing planform for flight style. [PDF]
Nat CommunWalters B +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
On the optimality of expert-adjusted forecasts [PDF]
Official forecasts of international institutions are never purely model-based. Preliminary results of models are adjusted with expert opinions. What is the impact of these adjustments for the forecasts? Are they necessary to get 'optimal' forecasts? When
P.H. Franses +2 more
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