Sertaconazole-Nitrate-Loaded Leciplex for Treating Keratomycosis: Optimization Using D-Optimal Design and In Vitro, Ex Vivo, and In Vivo Studies [PDF]
Pharmaceutics, 2022 This study aims to develop efficient topical therapy for keratomycosis using sertaconazolenitrate (STZN)-loaded leciplex (LP). The D-optimal design was used to optimize STZN-loaded LP by utilizing soy phosphatidylcholine (SPC) molar ratio (X1), cationic ...
Menna M. Abdellatif +3 more
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D-optimal Design for Preparation and Optimization of Fast Dissolving Bosentan Nanosuspension [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: Bosentan is a drug currently taken orally for the treatment of pulmonary arterialhypertension. However, the water solubility of bosentan is very low, resulting in lowbioavailability.
Elham Ghasemian +2 more
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Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study [PDF]
MoleculesMetformin (MET), an antidiabetic drug, is emerging as a promising anticancer agent. This study was initiated to investigate the antitumor effects and potential molecular targets of MET in mice bearing solid Ehrlich carcinoma (SEC) as a model of breast ...
Yasmina Elmahboub +7 more
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Information, 2023 In photolithographic processes, nanometer-level-precision wavefront-aberration models enable the machine to be able to meet the overlay (OVL) drift and critical dimension (CD) specifications.
Aris Magklaras +4 more
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D-Optimal Design Optimization for Esterification of Palm Fatty Acids Distillate with Polyhydric Alcohols for Biolubricants Production [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 Plant-based bio-lubricant is crucial to be developed and adopted by many industries. This is due to the presence of toxicity risk, climate change, energy security as well green-environmental approach issues.
Majd Ahmed Jumaah +2 more
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Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display Platform [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Production of functional recombinant antibody fragments in the periplasm of E. coli isa prerequisite step to achieve sufficient reagent for preclinical studies.
Marjan Abri Aghdam +6 more
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D-optimal design of experiments applied to 3D high-performance concrete printing mix design
Materials & Design, 2022 The development of 3D printable cement-based materials is a complex process with a variety of competing objectives. The compositions formed are far more complex than in conventional concrete, increasing the difficulty in designing mixtures for 3D ...
Vasileios Sergis +1 more
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A D-Optimal Sequential Calibration Design for Computer Models
Mathematics, 2022 The problem with computer model calibration by tuning the parameters associated with computer models is significant in many engineering and scientific applications.
Huaimin Diao, Yan Wang, Dianpeng Wang
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D-Optimal Design for a Causal Structure for Completely Randomized and Random Blocked Experiments
Journal of Probability and Statistics, 2022 Most experimental design literature on causal inference focuses on establishing a causal relationship between variables, but there is no literature on how to identify a design that results in the optimal parameter estimates for a structural equation ...
Zaher Kmail, Kent Eskridge
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Journal of Pharmacy and Bioallied Sciences, 2020 Introduction: Andrographolide is a compound that shows various pharmacological activities, which can be applied topically or orally. Nanoemulsion can improve drug solubility and stability, but has limitations for topical application.
Oktavia Indrati +3 more
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