Results 61 to 70 of about 1,217,382 (298)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Controlling the angle between the distal locking screw and tibiotalar joint tangent helps to reduce the occurrence of misalignment of distal tibial fractures treated with intramedullary nail fixation

BMC Musculoskeletal Disorders, 2022
Background Studies have shown that on the coronal plane, whether the direction of the distal locking screw is parallel to the tangent line of the tibiotalar joint can be used to determine whether there is varus or valgus deformity after the treatment of ...
Miao He, Jian Liu, Xu Deng, Miao He
doaj   +1 more source

ホッカイドウニジセイスルMentha arvensisノセイユセイブン [PDF]

, 2008
Present report deals with the essential oil components from a mint grown in Kinashibetsu- Hokkaido. The plant form of a mint was very similar to that of Mentha arvensis and could run to the seed.
梅本 和泰, 藤田 眞一
core   +1 more source

Magnetic and quadrupolar order in a one-dimensional ferromagnet with cubic crystal-field anisotropy

, 1999
The zero temperature phase diagram of a one-dimensional S=2 Heisenberg ferromagnet with single-ion cubic anisotropy is studied numerically using the density-matrix renormalization group method.
A. Aharony, A. I. Mitsek, B. M. McCoy, D. J. Newman, E. Barouch, E. Lieb, E. S. Sorensen, G. Fáth, H. H. Chen, H. Kleinert, J. Jensen, J. Sznajd, J. Sznajd, J. Sznajd, K. Nomura, K. Okamoto, M. Dudziński, M. Dudziński, M. Nauciel-Bloch, P. Erdős, P. Pfeuty, S. R. White, S. R. White, T. T. Wu, V. V. Valkov, Z. Domański, Ö. Legeza   +26 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A comprehensive investigation of memory impairment in attention deficit hyperactivity disorder and oppositional defiant disorder [PDF]

, 2012
We conducted a comprehensive and systematic assessment of memory functioning indrug-naïve boys with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD).
Alloway, American Psychiatric Association, Baddeley, Baddeley, Baddeley, Baddeley, Barkley, Bayliss, Cannon, Castellanos, Coghill, Coghill, Cowan, Dunn, D’Esposito, Faraone, Gathercole, Gibson, Happé, Holmes, Holmes, Jarrold, Jarvis, Karatekin, Kaufman, Kempton, Kim, Kline, Klingberg, Krauel, Luciana, Martinussen, Martinussen, Matthews, Morris, Narhi, Oosterlaan, Oosterlaan, Pennington, Rhodes, Rhodes, Rhodes, Rhodes, Rubia, Scheres, Schneider, Shue, Skowronek, Swanson, Teichner, Toren, Unsworth, Van Goozen, Verte, Willcutt, Willcutt   +55 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Identification and Anti-bacterial Testing of Staphylococcus aureus Isolated from Jollof Rice sold at selected Cafeterias in Federal University Dutse Campus, Jigawa State

UMYU Journal of Microbiology Research, 2019
This research was aimed at identifying Staphylococcus aureus isolated from jollof rice samples at selected cafeterias in Federal University Dutse campus.
Raji, M., Amoo, F. K., Adeleye, A. O., Amoo, A. O., Bate, G. B., Mohammed, S.   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source